Medication in elderly people: its influence on salivary pattern, signs and symptoms of dry mouth
Medication in elderly people: its influence on salivary pattern, signs and symptoms of dry mouth
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DOI：
10.1111/j.1741-2358.2009.00293.x
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发表时间：
2010-06-01
期刊：
影响因子：
2
通讯作者：
Zanotta, Pedro
中科院分区：
文献类型：
--
作者：
Leal, Soraya Coelho;Bittar, Juliana;Zanotta, Pedro
目的：比较老年痴呆用药组和健康对照组的唾液流量、pH值、缓冲能力、唾液流量、口干症的体征和症状。方法：将40例平均年龄68.5岁的老年痴呆患者按用药(G1)和不用药(G2)、有无痴呆(G2)分为两组。在回顾过程中收集了关于一般健康状况、用药情况和患者主诉的数据。临床检查发现与低位和口干有关的体征。结果：两组受试者的刺激性唾液流量均低于正常。G1中的个人使用的药物显示出干旱的潜力。口干症药物消耗量较高的人会出现嘴唇干燥和破裂。药物消耗量与缓冲能力(p<；0.001)和静息唾液流率(p=0.002)呈显著负相关。结论：药物的使用增加了老年人出现口干症状以及刺激唾液流量和缓冲能力改变的机会。
Objective:To compare stimulated and non-stimulated salivary flow, pH, buffering capacity and presence of signs and symptoms of hyposialie and xerostomia in elderly patients, with senile dementia using medication and healthy elderly subjects not using medication.Methods:Forty individuals (mean age: 68.5 years) were divided into two groups, according to the use (G1) or non-use (G2) of medication and the presence (G1) or absence (G2) of senile dementia. Data with reference to the general health condition, use of medication and the patient's complaints were collected during anamnesis. Clinical examination identified signs associated with hyposialie and xerostomia. Stimulated and non-stimulated saliva flow, pH and buffering capacity were verified.Results:The stimulated saliva flow in both groups was below normal parameters. The drugs used by individuals in G1 showed xerostomic potential. Individuals with a higher consumption of xerostomic medication presented with dry and cracked lips. A significant negative relationship was found between drugs consumption and the buffering capacity (p < 0.001), and the resting saliva flow rate (p = 0.002).Conclusion:The use of medication increases the chance that an elderly person may present signs related to xerostomia and alterations in stimulated saliva flow and buffering capacity.