Functions and mechanisms of long noncoding RNAs in lung cancer.
Functions and mechanisms of long noncoding RNAs in lung cancer.
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长链非编码RNA在肺癌中的功能和机制
DOI：
10.2147/ott.s109549
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发表时间：
2016
影响因子：
4
通讯作者：
Duan C
中科院分区：
文献类型：
--
作者：
Peng Z;Zhang C;Duan C
肺癌是一种异质性疾病，缺乏足够的生物标志物来诊断。长非编码RNA(Long Non Coding RNAs，LncRNAs)作为一组重要的分子，在细胞生长、细胞凋亡和肿瘤转移等多种重要的病理生理途径中发挥着重要作用。我们回顾了目前对肺癌中lncRNAs的认识。对肺癌中lncRNAs的深入分析增加了潜在有效生物标志物的数量，从而为增加治疗效益提供了选择。本文就lncRNAs在肺癌中的功能、机制和调控网络进行综述，为该领域的进一步研究奠定基础。
Lung cancer is a heterogeneous disease, and there is a lack of adequate biomarkers for diagnosis. Long noncoding RNAs (lncRNAs) are emerging as an important set of molecules because of their roles in various key pathophysiological pathways, including cell growth, apoptosis, and metastasis. We review the current knowledge of the lncRNAs in lung cancer. In-depth analyses of lncRNAs in lung cancer have increased the number of potential effective biomarkers, thus providing options to increase the therapeutic benefit. In this review, we summarize the functions, mechanisms, and regulatory networks of lncRNAs in lung cancer, providing a basis for further research in this field.