Progesterone-regulated cyclic modulation of membrane metalloendopeptidase (enkephalinase) in human endometrium.
Progesterone-regulated cyclic modulation of membrane metalloendopeptidase (enkephalinase) in human endometrium.
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DOI：
10.1016/s0021-9258(18)54460-4
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发表时间：
1991-12
期刊：
影响因子：
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通讯作者：
M. Casey;Jesse W. Smith;K. Nagai;L. Hersh;P. Macdonald
中科院分区：
文献类型：
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作者：
M. Casey;Jesse W. Smith;K. Nagai;L. Hersh;P. Macdonald
膜金属内肽酶（MMEP; EC 3.4.24.11; enkephalinase）催化内皮素、脑啡肽、心房利钠因子、P物质等小生物活性肽的降解。我们发现MMEP存在于人子宫内膜中，主要定位于该组织的基质细胞中，并且子宫内膜组织中MMEP（和免疫反应性MMEP蛋白）的特异性活性与血浆中黄体酮的浓度呈高度显著的正相关。在雌激素处理的单层培养的人子宫内膜基质细胞中，MMEP的比活性随着黄体酮的处理而增加；并且，这种增加伴随着免疫反应性MMEP蛋白、新合成的MMEP和MMEP mRNA的增加。
Membrane metalloendopeptidase (MMEP; EC 3.4.24.11; enkephalinase) catalyzes the degradation of endothelins, enkephalins, atrial natriuretic factor, substance P, and other small bioactive peptides. We found that MMEP is present in human endometrium, localized primarily in stromal cells of this tissue, and that the specific activity of MMEP (and immunoreactive MMEP protein) in endometrial tissue is correlated in a highly significant positive manner with the concentration of progesterone in plasma. In estrogen-treated, human endometrial stromal cells in monolayer culture, the specific activity of MMEP increases in response to treatment with progestin; and, this increase is accompanied by increases in immunoreactive MMEP protein, newly synthesized MMEP, and MMEP mRNA.