OVERVIEW OF STUDIES ON LIVER CARCINOGENESIS IN ENGLISH SOLE FROM PUGET SOUND - EVIDENCE FOR A XENOBIOTIC CHEMICAL ETIOLOGY .1. PATHOLOGY AND EPIZOOTIOLOGY
OVERVIEW OF STUDIES ON LIVER CARCINOGENESIS IN ENGLISH SOLE FROM PUGET SOUND - EVIDENCE FOR A XENOBIOTIC CHEMICAL ETIOLOGY .1. PATHOLOGY AND EPIZOOTIOLOGY
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DOI：
10.1016/0048-9697(90)90363-y
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发表时间：
1990-05-01
影响因子：
9.8
通讯作者：
MCCAIN, BB
中科院分区：
文献类型：
--
作者：
MYERS, MS;LANDAHL, JT;MCCAIN, BB
来自华盛顿州普吉特湾受污染的水道和海湾的野生英鲽（Parophrys vetulus）的肝脏受到多种共同发生的特发性肝脏病变的影响，包括肿瘤、假定的肿瘤前灶细胞改变和独特的变性情况。结果从统计分析的模式，这些病变共同出现在野生英国比目鱼表明，这些病变代表形态上可识别的步骤，导致肝脏肿瘤的发展。这个序列与啮齿类动物化学诱导肝癌的实验模型中的病变进展相似。野生英底鳎的这些病变可能是由于暴露于普吉特海湾的某些外源性肝毒性和肝癌化合物而引起的假设是基于：a)芳香烃（Σ AHs）和沉积物水平与这些特发性肝脏病变患病率之间的统计关联，b) Σ AHs在logistic回归模型中对肝脏肿瘤患病率变变性的贡献，c)普吉特海湾污染地区的几种特发性肝脏病变类型的优势比升高。d)特发性肝脏病变的患病率与英底鳎胆汁中芳香化合物（FACs）荧光代谢物水平之间存在显著相关性；e)实验诱导英底鳎的推定肿瘤前局灶性病变，注射了普吉特湾受污染城市沉积物提取物的富含多环芳烃的部分，其形态与来自同一部位的野生英底鳎的病变相同。
Livers of wild English sole (Parophrys vetulus) from polluted waterways and embayments of Puget Sound, Washington, are affected by a spectrum of multiple, co-occurring idiopathic hepatic lesions, including neoplasms, putative preneoplastic foci of cellular alteration, and unique degeneration conditions. Results from a statistical analysis of the patterns of co-occurrence of these lesions in wild English sole indicate that these lesions represent morphologically identifiable steps leading to the development of hepatic neoplasms. This sequence parallels the lesion progression in experimental models of chemically induced liver carcinogenesis in rodents. The hypothesis that these lesions in wild English sole can be caused by exposure to certain xenobiotic hepatotoxic and hepatocarcinogenic compounds in Puget Sound is based on: a) statistical associations between levels of aromatic hydrocarbons (Σ AHs) an sediment and prevalences of these idiopathic liver lesions, b) the contribution of Σ AHs in accounting for the variability in hepatic neoplasm prevalence in a logistic regression model, c) elevated odds ratios for several idiopathic hepatic lesion types in sole from polluted sites in Puget Sound, d) significant correlations between prevalences of idiopathic hepatic lesions and levels of fluorescent metabolites of aromatic compounds (FACs) in bile of English sole, and e) experimental induction of putatively preneoplastic focal lesions in English sole injected with a PAH-enriched fraction of an extract from a contaminated urban sediment from Puget Sound, that were morphologically identical to lesions found in wild English sole from the same site.