SURGICAL SALVAGE OF THE OROPHARYNX AFTER FAILURE OF ORGAN-SPARING THERAPY
SURGICAL SALVAGE OF THE OROPHARYNX AFTER FAILURE OF ORGAN-SPARING THERAPY
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DOI：
10.1002/hed.21480
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发表时间：
2011-04-01
影响因子：
2.9
通讯作者：
Rocco, James W.
中科院分区：
文献类型：
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作者：
Nichols, Anthony C.;Kneuertz, Peter J.;Rocco, James W.
背景本研究的目的是评估挽救性手术治疗口咽鳞状细胞癌局部复发的疗效并确定生存预测因素。作者回顾性分析了264例接受放疗或放化疗的OPSCC患者。在77例复发患者中，37例为局部或局部和区域复发，考虑进行挽救性手术。37例局部或局部和区域复发患者中，5例不能手术切除，3例拒绝手术。其余患者接受了挽救性手术，2年和5年生存率分别为64.5%和43.4%。酗酒史和手术切缘阳性是挽救性手术后总生存率较低的唯一预测因素（p <0.05）。局部复发的手术挽救是有效的，如果广泛切除，使阴性边缘可以实现。(C)2010 Wiley Periodicals，Inc.头颈部33：516-524，2011年
Background. The purpose of this study was to evaluate the efficacy of salvage surgery for local recurrences of oropharyngeal squamous cell carcinoma (OPSCC) and identify predictors of survival.Methods. The authors reviewed 264 patients with OPSCC treated with radiation or chemoradiation identified retrospectively. Of the 77 patients that experienced recurrences, 37 had local or local and regional recurrences and were considered for salvage surgery.Results. Of the 37 patients with local or local and regional recurrence, 5 had unresectable disease whereas 3 refused surgery. The remainder underwent salvage surgery with 2-year and 5-year survival rates of 64.5% and 43.4%, respectively. A history of alcohol abuse and positive surgical margins were the only predictors of poorer overall survival (p < .05) after salvage surgery.Conclusion. Surgical salvage of locoregional recurrences can be effective if wide resections are performed so that negative margins can be achieved. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 516-524, 2011