A guide to chemokines and their receptors.
A guide to chemokines and their receptors.
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DOI：
10.1111/febs.14466
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Nibbs RJB
中科院分区：
文献类型：
--
作者：
Hughes CE;Nibbs RJB
趋化因子（或趋化性细胞因子）是一个大家族的小，分泌的蛋白质，通过细胞表面G蛋白偶联的七螺旋趋化因子受体的信号。它们最出名的是刺激细胞迁移的能力，最明显的是白色血细胞（白细胞）。因此，趋化因子在免疫系统的发育和稳态中起着核心作用，并参与所有保护性或破坏性免疫和炎症反应。趋化因子通常被认为是定向趋化性迁移的诱导物，现在清楚的是，趋化因子除了诱导细胞停滞或粘附之外，还可以刺激各种其他类型的定向和非定向迁移行为，如趋触性、化学运动和触动。然而，白细胞上的趋化因子受体不仅可以直接迁移，而且这些分子也可以在许多非白细胞类型上表达并调节其生物学特性。趋化因子受到翻译后修饰、与细胞外基质（ECM）相互作用以及与调节趋化因子定位和丰度的七螺旋“非典型”趋化因子受体结合的深刻影响。本指南对趋化因子和趋化因子受体家族进行了广泛的概述;总结了趋化因子网络中发生的复杂的物理相互作用;并使用特定的例子，讨论了趋化因子功能的一般原理，特别关注它们指导白细胞迁移的能力。
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are best known for their ability to stimulate the migration of cells, most notably white blood cells (leukocytes). Consequently, chemokines play a central role in the development and homeostasis of the immune system, and are involved in all protective or destructive immune and inflammatory responses. Classically viewed as inducers of directed chemotactic migration, it is now clear that chemokines can stimulate a variety of other types of directed and undirected migratory behavior, such as haptotaxis, chemokinesis, and haptokinesis, in addition to inducing cell arrest or adhesion. However, chemokine receptors on leukocytes can do more than just direct migration, and these molecules can also be expressed on, and regulate the biology of, many nonleukocytic cell types. Chemokines are profoundly affected by post‐translational modification, by interaction with the extracellular matrix (ECM), and by binding to heptahelical ‘atypical’ chemokine receptors that regulate chemokine localization and abundance. This guide gives a broad overview of the chemokine and chemokine receptor families; summarizes the complex physical interactions that occur in the chemokine network; and, using specific examples, discusses general principles of chemokine function, focusing particularly on their ability to direct leukocyte migration.
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DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
7.3
作者：
Adage, Tiziana;Piccinini, Anna-Maria;Kungl, Andreas J.
通讯作者：
Kungl, Andreas J.
影响因子：
4.4
作者：
Abel, S;Hundhausen, C;Ludwig, A
通讯作者：
Ludwig, A
影响因子：
4.4
作者：
Berahovich, RD;Miao, ZH;Schall, TJ
通讯作者：
Schall, TJ
影响因子：
64.8
作者：
Ansel, KM;Ngo, VN;Cyster, JG
通讯作者：
Cyster, JG