Effect of hydrolyzed guar fiber on fasting and postprandial satiety and satiety hormones: A double-blind, placebo-controlled trial during controlled weight loss
Effect of hydrolyzed guar fiber on fasting and postprandial satiety and satiety hormones: A double-blind, placebo-controlled trial during controlled weight loss
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DOI：
10.1038/sj.ijo.0800680
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发表时间：
1998-09-01
影响因子：
4.9
通讯作者：
Weinsier, RL
中科院分区：
文献类型：
--
作者：
Heini, AF;Lara-Castro, C;Weinsier, RL
目的：评估完全可溶性纤维在受控减肥计划期间对空腹和餐后激素水平、呼吸商 (RQ) 和饱腹感主观评分的影响。 设计：在一项为期五周的前瞻性、随机、双盲研究中，在两周的调整期内提供 3.3 MJ（800 kcal）/天的饮食。然后，在干预周期间，间隔一周的清除期，以交叉设计的方式每天给予含有 20 克纤维或安慰剂的 3.3 MJ（800 kcal）配方奶粉，并在干预周的第 1、3 和 7 天（第 3 周和第 5 周）禁食过夜后进行测量。 受试者：25 名肥胖但其他方面健康的女性（年龄：46 +/- 6 岁，体重指数(BMI)：35 +/- 6 kg/m(2)) 研究。测量：体重；饥饿/饱腹感等级；葡萄糖、胰岛素、胆囊收缩素 (CCK) 和瘦素浓度；干预周期间的 RQ。 结果：在禁食状态下，补充剂对任何测量参数都没有影响，包括血糖、胰岛素、CCK 和瘦素的血液浓度、RO 和饱腹感等级。在测试餐后的餐后 2 小时内，除了 CCK 反应外，测量的参数与非纤维补充餐后的参数没有显着差异。即使在调整了年龄、体重、身高和治疗顺序后，CCK 在添加纤维的膳食后表现出整体较高的浓度 (P = 0.007)。 CCK 的餐后峰值也出现在完成添加纤维的膳食后较早的时间（15 分钟与 30 分钟）。结论：结果表明，水解瓜尔豆胶纤维补充剂产生增强的餐后 CCK 反应，但在空腹或餐后状态下不会改变其他饱腹感激素或增加饱腹感等级。
OBJECTIVE: To evaluate the effects of a completely soluble fiber on fasting and postprandial hormone levels, respiratory quotient (RQ) and subjective ratings of satiety during a controlled weight-loss program.DESIGN: In a five-week prospective, randomized, double-blind study, a 3.3 MJ (800 kcal)/d diet was provided during a two-week wash-in period. Then, during the intervention weeks, separated by a one-week wash-out period, a 3.3 MJ (800 kcal) formula containing either 20 g fiber or placebo daily, was given in a cross-over design and on days 1, 3 and 7 of the intervention weeks (weeks 3 and 5) measurements were taken after an overnight fast.SUBJECTS: 25 obese but otherwise healthy females (age: 46 +/- 6 y, body mass index (BMI): 35 +/- 6 kg/m(2)) were studied.MEASUREMENTS: Body weight; hunger/satiety ratings; glucose, insulin, cholecystokinin (CCK) and leptin concentrations; RQ during the intervention weeks.RESULTS: In the fasting state, the supplement had no effect on any of the measured parameters, including blood concentrations of glucose, insulin, CCK, and leptin, RO and satiety ratings. In the 2 h postprandial period following the test meal, none of the measured parameters differed significantly from that following the non-fiber-supplemented meal, except for the CCK response. CCK demonstrated an overall higher concentration after the fiber-supplemented meal (P = 0.007), even after adjustment for age, weight, height and treatment sequence. The postprandial peak in CCK also occurred earlier (at 15 min vs 30 min) after completion of the fiber-supplemented meal.CONCLUSIONS: The results indicated that a hydrolyzed guar gum fiber supplement produced a heightened postprandial CCK response, but did not alter other satiety hormones or increase satiety ratings, in either the fasting or the postprandial state.