INTRINSIC NEUROMUSCULAR DEFECTS IN THE NEUROGENIC BLADDER 2. LONG-TERM INNERVATION OF THE UNILATERALLY DECENTRALIZED FELINE BLADDER BASE BY REGENERATED CHOLINERGIC INCREASED ADRENERGIC AND EMERGENT PROBABLE PEPTIDERGIC NERVES
INTRINSIC NEUROMUSCULAR DEFECTS IN THE NEUROGENIC BLADDER 2. LONG-TERM INNERVATION OF THE UNILATERALLY DECENTRALIZED FELINE BLADDER BASE BY REGENERATED CHOLINERGIC INCREASED ADRENERGIC AND EMERGENT PROBABLE PEPTIDERGIC NERVES
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DOI：
10.1002/nau.1930030308
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发表时间：
1984-01-01
影响因子：
2
通讯作者：
ELBADAWI A
中科院分区：
文献类型：
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作者：
ATTA M A;FRANCK J I;ELBADAWI A
用单侧骶神经腹根切断法，对猫膀胱基底部肌性神经支配的超微结构进行了观察。在所有的样本中，有广泛的再生胆碱能轴突，显示初始跨突触变性手术后几周，重组胆碱能神经效应器连接。这与肾上腺素能轴突的反应性发芽导致肾上腺素能神经支配过度，以及出现了一个人口的胆碱能和肾上腺素能轴突含有惊人丰富的多形大致密核心囊泡，类似于那些自然存在于副神经节细胞，paradrons和神经分泌细胞。这种大的致密核心囊泡的含量增加赋予了一些再生和许多反应性发芽肾上腺素能轴突可能的肽能特性。显然，副交感神经分散膀胱基础的长期功能障碍是由重新建立的胆碱能，肾上腺素能，并出现可能的肽能轴突的影响和神经效应传递的相互作用。
The ultrastructure of muscular innervation of the feline bladder base was studied 8 and 10 wk following its decentralization by unilateral sacral ventral rhizotomy. In all samples, there was widespread regeneration of cholinergic axons that displayed initial transsynaptic degeneration a few weeks after the operation, with reformation of cholinergic neuroeffector junctions. This was associated with reactive sprouting of adrenergic axons leading to adrenergic hyperinnervation, as well as the emergence of a population of cholinergic and adrenergic axons containing strikingly abundant polymorphous large dense-core vesicles that resembled those naturally present in paraganglionic cells, paraneurons and neurosecretory cells. This increased content of large dense-core vesicles imparts a probable peptidergic character to some regenerating and many reactively sprouting adrenergic axons. Apparently, the long-term dysfunction of the parasympathetic-decentralized bladder base is determined by the interplay of reestablished cholinergic, exaggerated adrenergic, and emergence probable peptidergic axonal influence and neuroeffector transmission.