Using MIMIC models to examine the relationship between current smoking and early smoking experiences
Using MIMIC models to examine the relationship between current smoking and early smoking experiences
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DOI：
10.1093/ntr/ntp093
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发表时间：
2009-09-01
影响因子：
4.7
通讯作者：
Pomerleau, Ovide F.
中科院分区：
文献类型：
--
作者：
Rios-Bedoya, Carlos F.;Pomerleau, Cynthia S.;Pomerleau, Ovide F.
本研究通过多指标多原因（MIMIC）模型扩展了以往关于早期烟草体验的研究，该模型允许将愉快体验的指标结合到一个潜在结构中，将不愉快体验的指标结合到另一个潜在结构中。使用早期吸烟经历问卷评估对早期吸烟实验的反应，其中参与者被问到以下问题：“您第一次尝试吸烟时，是否经历过以下任何情况？（愉快和难以测量的感觉[总体]、愉快的冲动或嗡嗡声、头晕、放松、恶心、咳嗽、吸气困难）。“这些经历的评分范围从1 =无到4 =强烈。MIMIC模型显示，目前的吸烟状况和最初尝试吸烟的年龄与早期愉快和不愉快的经历显著相关（p <0.05）。非裔美国人比白人更不可能有早期不愉快的经历（p <0.05）。种族和早期愉快的经历之间没有关联，我们的研究结果与以下推论一致：早期吸烟实验的愉快经历导致经常吸烟，积极的经历在向经常吸烟的过渡中比消极的经历起着更大的作用。我们的研究还表明，MIMIC模型是相关的和可行的尼古丁和吸烟的研究。我们建议它作为一个有用的工具，用于识别与尼古丁依赖和烟草使用的潜在结构相关的内表型。
The present study expands previous research on early experiences with tobacco by using a Multiple Indicator Multiple Causes (MIMIC) model, which permits combining indicators tapping into pleasant experiences into one latent construct and those indicators of unpleasant experiences into another latent construct.A sample of 458 participants was recruited via newspaper advertisements. Response to early experimentation with cigarettes was assessed using the Early Smoking Experiences questionnaire, in which participants were asked the following question: "The first time you tried cigarettes, did you experience any of the following? (pleasurable and displeasurable sensations [overall], pleasurable rush or buzz, dizziness, relaxation, nausea, cough, difficulty inhaling)." These experiences were rated on a scale ranging from 1 = none to 4 = intense.The MIMIC model revealed that current smoking status and age of initial experimentation with cigarettes were significantly associated with both early pleasant and unpleasant experiences (p < .05). African Americans were less likely than Whites to have early unpleasant experiences (p < .05). No association was found between race and early pleasant experiences.Our findings are consistent with the inferences that pleasant experiences in response to early experimentation with smoking lead to regular smoking and that positive experiences play a stronger role than negative experiences in the transition to regular smoking. Our study also demonstrates that the MIMIC model is pertinent and practicable in nicotine and smoking research. We recommend it as a useful tool for identifying endophenotypes related to nicotine dependence and tobacco use latent constructs.