Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability
Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability
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DOI：
10.1152/ajpheart.01222.2010
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发表时间：
2011-07-01
影响因子：
4.8
通讯作者：
Kintscher, Ulrich
中科院分区：
文献类型：
--
作者：
Foryst-Ludwig, Anna;Kreissl, Michael C.;Kintscher, Ulrich
Foryst-Ludwig A, Kreissl MC, Sprang C, Thalke B, Bohm C, Benz V, Gurgen D, Dragun D, Schubert C, Mai K, Stawowy P, Spranger J, Regitz-Zagrosek V, Unger T, Kintscher U.生理心肌肥厚的性别差异与运动调节的能量底物可得性变化有关。[J] .中国生物医学工程学报，2011,31(2):557 - 557。首次发表于2011年4月8日；doi: 10.1152 / ajpheart.01222.2010。-运动引起的心脏肥厚最近被发现以一种性别特异性的方式调节。与此同时，与男性相比，女性表现出更强的运动介导的脂肪分解，这可能与心脏反应有关。本研究的目的是评估先前报道的运动期间心脏肥厚反应的性别依赖性差异是否与心脏能量底物可用性/利用率的差异有关。雌性和雄性C57BL/6J小鼠在4周内以1.5 h/天（0.25 m/s）的速度在跑步机上运动。小鼠进行了心脏和代谢表型分析，包括超声心动图、小动物PET、运动前后间接量热法，以及脂肪组织（AT）脂肪分解和心脏基因表达分析。超声心动图显示，与雄性小鼠相比，雌性小鼠对运动表现出增加的心脏肥厚反应[左心室质量（LVM）增加百分比：雌性：22.2 +/- 0.8%，雄性：9.0 +/- 0.2%；P < 0.05]。这与训练后雌性小鼠血浆游离脂肪酸（FFA）水平增加和AT脂肪分解增加有关，而雄性小鼠的FFA水平则下降。雌性小鼠运动时的呼吸商明显降低，表明脂肪酸的优先利用。同时，通过PET{注射剂量(ID)/LVM [%ID/g]分析，运动后雌性小鼠心肌葡萄糖摄取减少：久坐雌性小鼠36.8 +/- 3.5 vs.运动雌性小鼠28.3 +/- 4.3；P < 0.05}，而运动后心脏葡萄糖摄取没有改变。与雄性小鼠相比，雌性小鼠参与脂肪酸摄取/氧化的心脏基因增加。总的来说，我们的数据表明，运动引起的心脏肥厚的性别差异与心脏底物可用性和利用的变化有关。
Foryst-Ludwig A, Kreissl MC, Sprang C, Thalke B, Bohm C, Benz V, Gurgen D, Dragun D, Schubert C, Mai K, Stawowy P, Spranger J, Regitz-Zagrosek V, Unger T, Kintscher U. Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability. Am J Physiol Heart Circ Physiol 301: H115-H122, 2011. First published April 8, 2011; doi:10.1152/ajpheart.01222.2010.-Exercise-induced cardiac hypertrophy has been recently identified to be regulated in a sex-specific manner. In parallel, women exhibit enhanced exercise-mediated lipolysis compared with men, which might be linked to cardiac responses. The aim of the present study was to assess if previously reported sex-dependent differences in the cardiac hypertrophic response during exercise are associated with differences in cardiac energy substrate availability/utilization. Female and male C57BL/6J mice were challenged with active treadmill running for 1.5 h/day (0.25 m/s) over 4 wk. Mice underwent cardiac and metabolic phenotyping including echocardiography, small-animal PET, peri-exercise indirect calorimetry, and analysis of adipose tissue (AT) lipolysis and cardiac gene expression. Female mice exhibited increased cardiac hypertrophic responses to exercise compared with male mice, measured by echocardiography [percent increase in left ventricular mass (LVM): female: 22.2 +/- 0.8%, male: 9.0 +/- 0.2%; P < 0.05]. This was associated with increased plasma free fatty acid (FFA) levels and augmented AT lipolysis in female mice after training, whereas FFA levels from male mice decreased. The respiratory quotient during exercise was significantly lower in female mice indicative for preferential utilization of fatty acids. In parallel, myocardial glucose uptake was reduced in female mice after exercise, analyzed by PET {injection dose (ID)/LVM [%ID/g]: 36.8 +/- 3.5 female sedentary vs. 28.3 +/- 4.3 female training; P < 0.05}, whereas cardiac glucose uptake was unaltered after exercise in male counterparts. Cardiac genes involved in fatty acid uptake/oxidation in females were increased compared with male mice. Collectively, our data demonstrate that sex differences in exercise-induced cardiac hypertrophy are associated with changes in cardiac substrate availability and utilization.