CIMOXATONE IS A REVERSIBLE TIGHT-BINDING INHIBITOR OF THE A FORM OF RAT-BRAIN MONOAMINE-OXIDASE
CIMOXATONE IS A REVERSIBLE TIGHT-BINDING INHIBITOR OF THE A FORM OF RAT-BRAIN MONOAMINE-OXIDASE
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DOI：
10.1111/j.1471-4159.1983.tb11312.x
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发表时间：
1983-01-01
影响因子：
4.7
通讯作者：
BENEDETTI, MS
中科院分区：
文献类型：
--
作者：
FOWLER, CJ;BENEDETTI, MS
Cimoxatone是一种完全可逆的单胺氧化酶A型选择性抑制剂。这种抑制对这种酶形式是如此有效，以至于它起到了紧密结合的抑制作用。这种抑制剂的使用表明，在大鼠脑匀浆中，单胺氧化酶A的浓度约为8-11pmol/mg蛋白。用Clorgyline滴定得到与此类似的值，两种方法得到的值与[~3H]骆驼蓬碱结合法得到的值相似。
Cimoxatone is a fully reversible inhibitor selective for the A form of monoamine oxidase. The inhibition is so potent against this enzyme form that it acts as a tight-binding inhibitor. Use of this inhibitor indicates that in rat brain homogenates the concentration of monoamine oxidase A is approximately 8-11 pmol/mg protein. Values similar to this were obtained by clorgyline titration, and both methods gave values similar to those found with a [3H]harmaline binding assay.