Longitudinal changes of resting-state functional connectivity during motor recovery after stroke.
Longitudinal changes of resting-state functional connectivity during motor recovery after stroke.
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DOI：
10.1161/strokeaha.110.596155
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发表时间：
2011-05
期刊：
影响因子：
8.3
通讯作者：
Kim YH
中科院分区：
文献类型：
--
作者：
Park CH;Chang WH;Ohn SH;Kim ST;Bang OY;Pascual-Leone A;Kim YH
功能磁共振成像（fMRI）研究可以提供关键信息的神经机制的运动恢复中风患者。静息状态功能磁共振成像适用于不能正常执行运动任务的中风患者。在这项研究中，我们探讨了运动恢复的神经相关的中风患者通过调查的纵向变化，在静息状态下的功能连接的同侧初级运动皮层（M1）。对12例脑卒中患者进行了一项使用重复fMRI实验的纵向观察研究。在6个月的时间里，静息状态的fMRI数据被采集了四次。患者在发病后不久参加了第一次fMRI检查，此后在发病后1、3和6个月参加了随后的检查。静息状态的同病灶M1的功能连接进行了评估，并与健康受试者进行了比较。与健康受试者相比，患者表现出更高的功能连接同侧额叶和顶叶皮质，双侧丘脑，小脑。相反，中风患者与对侧病灶M1和枕叶皮质的功能连接减少。发病后1个月，同侧和对侧病灶M1之间的功能连接显示同侧病灶最不对称。发病时同侧病灶M1与对侧病灶丘脑、辅助运动区和额中回的功能连接与卒中后6个月的运动恢复呈正相关。静息状态下的功能磁共振成像引起了独特的，但与以前的任务为基础的功能磁共振成像的结果，提出了补充和实用价值，用于中风患者的研究。
Functional magnetic resonance imaging (fMRI) studies could provide crucial information on the neural mechanisms of motor recovery in stroke patients. Resting-state fMRI is applicable to stroke patients who are not capable of proper performance of the motor task. In this study, we explored neural correlates of motor recovery in stroke patients by investigating longitudinal changes in resting-state functional connectivity of the ipsilesional primary motor cortex (M1). A longitudinal observational study using repeated fMRI experiments was conducted in 12 patients with stroke. Resting-state fMRI data were acquired four times over a period of 6 months. Patients participated in the first session of fMRI shortly after onset, and thereafter in subsequent sessions at 1, 3, and 6 months after onset. Resting-state functional connectivity of the ipsilesional M1 was assessed and compared with that of healthy subjects. Compared with healthy subjects, patients demonstrated higher functional connectivity with the ipsilesional frontal and parietal cortices, bilateral thalamus, and cerebellum. Instead, functional connectivity with the contralesional M1 and occipital cortex were decreased in stroke patients. Functional connectivity between the ipsilesional and contralesional M1 showed the most asymmetry at 1 month after onset to the ipsilesional side. Functional connectivity of the ipsilesional M1 with the contralesional thalamus, supplementary motor area, and middle frontal gyrus at onset was positively correlated with motor recovery at 6 months after stroke. Resting-state fMRI elicited distinctive but comparable results with previous task-based fMRI, presenting complementary and practical values for use in the study of stroke patients.