L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers.
L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers.
复制标题
L1 是 β-连环蛋白信号传导的新靶标，可转化细胞并在结肠癌的侵袭性前沿表达。
DOI：
10.1083/jcb.200408051
复制
发表时间：
2005-02-14
影响因子：
7.8
通讯作者：
Ben-Ze'ev, A
中科院分区：
文献类型：
--
作者：
Gavert, N;Conacci-Sorrell, M;Gast, D;Schneider, A;Altevogt, P;Brabletz, T;Ben-Ze'ev, A
β-catenin-TCF靶基因的异常激活在结直肠癌的起始阶段和侵袭转移过程中都起着关键作用。我们在结直肠癌细胞中发现了神经元细胞粘附分子L1作为β-catenin-TCF信号传导的靶基因。L1在稀疏培养中高表达，并与ADAM10（一种参与L1细胞外结构域切割和脱落的金属蛋白酶）共同调节。L1表达增加了细胞活力、低血清生长、转化和肿瘤发生，而在结肠癌细胞中抑制L1表达则降低了细胞活力。L1与ADAM10仅局限于人类结直肠肿瘤的侵袭性前部。金属蛋白酶的跨膜定位和L1的脱落可作为结肠癌检测和治疗的靶点。
Aberrant β-catenin-TCF target gene activation plays a key role in colorectal cancer, both in the initiation stage and during invasion and metastasis. We identified the neuronal cell adhesion molecule L1, as a target gene of β-catenin-TCF signaling in colorectal cancer cells. L1 expression was high in sparse cultures and coregulated with ADAM10, a metalloprotease involved in cleaving and shedding L1's extracellular domain. L1 expression conferred increased cell motility, growth in low serum, transformation and tumorigenesis, whereas its suppression in colon cancer cells decreased motility. L1 was exclusively localized in the invasive front of human colorectal tumors together with ADAM10. The transmembrane localization and shedding of L1 by metalloproteases could be useful for detection and as target for colon cancer therapy.
登录
查看更多内容
DOI：
10.1073/pnas.96.4.1603
发表时间：
1999-02-16
影响因子：
11.1
作者：
Mann, B;Gelos, M;Hanski, C
通讯作者：
Hanski, C
影响因子：
15.9
作者：
Conacci-Sorrell, M;Zhurinsky, J;Ben-Ze'ev, A
通讯作者：
Ben-Ze'ev, A
DOI：
10.1073/pnas.96.5.2420
发表时间：
1999-03-02
影响因子：
11.1
作者：
Meech, R;Kallunki, P;Jones, FS
通讯作者：
Jones, FS
影响因子：
56.9
作者：
He, TC;Sparks, AB;Kinzler, KW
通讯作者：
Kinzler, KW
影响因子：
6
作者：
Brabletz, T;Jung, A;Kirchner, T
通讯作者：
Kirchner, T