Stress sensitization and adolescent depressive severity as a function of childhood adversity: A link to anxiety disorders
Stress sensitization and adolescent depressive severity as a function of childhood adversity: A link to anxiety disorders
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DOI：
10.1007/s10802-006-9090-3
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发表时间：
2007-04-01
影响因子：
3.6
通讯作者：
Bor, William
中科院分区：
文献类型：
--
作者：
Espejo, Emmanuel P.;Hammen, Constance L.;Bor, William
本研究的目的是确定是否暴露在逆境中的童年有助于差异阈值的压力生活事件在青春期引起抑郁反应。此外，为了解决有关压力效应的经验和概念问题，还探讨了焦虑症病史的调节作用。这项研究是在816名母亲患有抑郁症和非抑郁症的儿童中进行的，这些儿童从出生到15岁一直被跟踪。关于童年经历的逆境的信息是从青少年生命的前五年的母亲和15岁的青少年本身收集的，包括关于母亲与其伴侣的关系、母亲的精神病理学以及青少年报告的虐待的信息。结果表明，与只有一个或没有这些危险因素的年轻人相比，在童年时期有更多的逆境和焦虑症病史的年轻人在低水平的情景压力下表现出更严重的抑郁。这些结果被推测反映了与童年时期暴露于逆境相关的早期焦虑症可能是压力反应失调的标志，并可能有助于解释某些个体中抑郁和焦虑的共病。
The goal of the present study was to determine whether exposure to adversity in childhood contributes to a differential threshold at which stressful life events provoke depressive reactions in adolescence. In addition, to address empirical and conceptual questions about stress effects, the moderating effect of anxiety disorder history was also explored. This examination was conducted in a sample of 816 children of depressed and nondepressed mothers, who were followed from birth to age 15. Information on adversities experienced in childhood was collected both from mothers during the first five years of their youth's life and from the youths themselves at age 15, and included information on the mother's relationship with her partner, maternal psychopathology, as well as youth-reported abuse. Results indicated that youths with both greater exposure to adversity in childhood and a history of an anxiety disorder displayed increased depressive severity following low levels of episodic stress compared to youths with only one or neither of these risk factors. The results are speculated to reflect the possibility that early anxiety disorders associated with exposure to adversity in childhood may be a marker of dysregulated stress responses, and may help to account for the comorbidity of depression and anxiety in some individuals.