Immunoglobulin E plays an immunoregulatory role in lupus.
Immunoglobulin E plays an immunoregulatory role in lupus.
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DOI：
10.1084/jem.20140066
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发表时间：
2014-10-20
期刊：
影响因子：
--
通讯作者：
Rivera J
中科院分区：
文献类型：
--
作者：
Dema B;Charles N;Pellefigues C;Ricks TK;Suzuki R;Jiang C;Scheffel J;Hasni S;Hoffman V;Jablonski M;Sacré K;Gobert D;Papo T;Daugas E;Crampton S;Bolland S;Rivera J
德马等人。有证据表明，IgE 缺乏会延缓狼疮样疾病的发展和严重程度，正如自身抗体产生减少和器官病理改善所证明的那样。 IgE 的缺失会导致次级淋巴器官中的先天免疫细胞浸润显着减少，并导致 T 细胞和嗜碱性粒细胞的活化减少。 IgE 在非过敏性炎症性疾病中的（病理）生理作用尚不清楚。在这里，我们探讨了 IgE 缺乏对 FcγRIIB 缺陷小鼠以及携带 FcγRIIB 缺失和 Y 连锁自身免疫加速 (Yaa) 染色体易位的小鼠炎症反应的影响，Yaa 加速并导致这些小鼠出现更具侵袭性的狼疮样疾病。研究结果表明，IgE 缺乏会延缓疾病的发展和严重程度，这一点可以通过自身抗体产生的减少和器官病理的改善来证明。这与浆细胞数量减少以及 IgG2b 和 IgG3 水平降低有关。出乎意料的是，IgE 的缺失还导致次级淋巴器官中免疫细胞浸润的显着减少，对这些器官中树突状细胞、单核细胞、中性粒细胞和嗜酸性粒细胞的存在产生显着影响，并减少嗜碱性粒细胞的活化。人类系统性红斑狼疮受试者中自身反应性 IgE 的存在也与嗜碱性粒细胞活化增加和疾病活动增强相关。这些发现表明 IgE 促进自身免疫炎症的放大。
Dema et al. show evidence that deficiency of IgE delays lupuslike disease development and severity, as demonstrated by reduced autoantibody production and amelioration of organ pathologies. Loss of IgE causes a striking decrease in innate immune cell infiltration in secondary lymphoid organs and decreased activation of T cells and basophils. The (patho)physiological role of IgE in nonallergic inflammatory diseases is not well understood. Here, we explored the effect of IgE deficiency on the inflammatory response in FcγRIIB-deficient mice as well as in mice carrying both a deletion of FcγRIIB and the chromosomal translocation of Y-linked autoimmune acceleration (Yaa) that hastens and results in a more aggressive lupuslike disease in these mice. The findings show that deficiency of IgE delays disease development and severity as demonstrated by reduced autoantibody production and amelioration of organ pathologies. This was associated with decreased numbers of plasma cells and reduced levels of IgG2b and IgG3. Unexpectedly, the loss of IgE also caused a striking decrease of immune cell infiltration in secondary lymphoid organs with a marked effect on the presence of dendritic cells, monocytes, neutrophils, and eosinophils in these organs and decreased activation of basophils. The presence of autoreactive IgE in human systemic lupus erythematosus subjects was also associated with increased basophil activation and enhanced disease activity. These findings argue that IgE facilitates the amplification of autoimmune inflammation.
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DOI：
10.1111/j.1365-2222.2008.03154.x
发表时间：
2009-03
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Torrero MN;Larson D;Hübner MP;Mitre E
通讯作者：
Mitre E
DOI：
10.1084/jem.20110845
发表时间：
2011-10-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Porcherie A;Mathieu C;Peronet R;Schneider E;Claver J;Commere PH;Kiefer-Biasizzo H;Karasuyama H;Milon G;Dy M;Kinet JP;Louis J;Blank U;Mécheri S
通讯作者：
Mécheri S
影响因子：
30.5
作者：
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--
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
64.8
作者：
OETTGEN, HC;MARTIN, TR;LEDER, P
通讯作者：
LEDER, P