Adipose Tissue-Derived Stem Cells for Myocardial Regeneration.
Adipose Tissue-Derived Stem Cells for Myocardial Regeneration.
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DOI：
10.4070/kcj.2016.0207
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发表时间：
2017-03
影响因子：
2.9
通讯作者：
Hong SJ
中科院分区：
文献类型：
--
作者：
Joo HJ;Kim JH;Hong SJ
在过去的十年里，干细胞治疗在心脏疾病的临床应用中得到了广泛的研究。在众多干细胞中，脂肪组织来源的干细胞(ADSC)因其含量丰富、易于获取而仍然是一种有吸引力的干细胞来源。体外研究表明，ADSC具有多向分化潜能，甚至分化为心肌细胞。许多临床前动物研究也证明了ADSC有良好的治疗效果。此外，有几项临床试验显示ADSC在急性心肌梗死中的阳性结果。本文简要介绍了ADSC用于心肌再生的治疗机制、应用方法(包括细胞剂量和给药)以及人体临床试验。
Over the past decade, stem cell therapy has been extensively studied for clinical application for heart diseases. Among various stem cells, adipose tissue-derived stem cell (ADSC) is still an attractive stem cell resource due to its abundance and easy accessibility. In vitro studies showed the multipotent differentiation potentials of ADSC, even differentiation into cardiomyocytes. Many pre-clinical animal studies have also demonstrated promising therapeutic results of ADSC. Furthermore, there were several clinical trials showing the positive results in acute myocardial infarction using ADSC. The present article covers the brief introduction, the suggested therapeutic mechanisms, application methods including cell dose and delivery, and human clinical trials of ADSC for myocardial regeneration.