Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway.
Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway.
复制标题
SOCS3调控通路介导黄芩苷对实验性自身免疫性脑脊髓炎的治疗作用
DOI：
10.1038/srep17407
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发表时间：
2015-11-30
影响因子：
4.6
通讯作者：
Zhang GX
中科院分区：
文献类型：
--
作者：
Zhang Y;Li X;Ciric B;Ma CG;Gran B;Rostami A;Zhang GX
来源于药用植物的天然化合物一直被认为是新型治疗剂的丰富来源。黄芩苷（Baicalin，Ba）是一种从中药黄芩中提取的具有生物活性的黄酮类化合物，广泛用于治疗各种炎症性疾病。在这项研究中，我们调查的影响和Ba在实验性自身免疫性脑脊髓炎（EAE），多发性硬化症（MS）的动物模型的作用机制。Ba治疗有效地改善了髓鞘少突胶质细胞糖蛋白（MOG）35-55肽诱导的EAE的临床疾病严重程度，并减少了中枢神经系统（CNS）的炎症和脱髓鞘。Ba通过STAT/NFκB信号通路减少免疫细胞向CNS的浸润，抑制促炎分子和趋化因子的表达，并阻止Th 1和Th 17细胞分化。此外，我们发现SOCS 3诱导对Ba的作用至关重要，因为当SOCS 3信号转导被敲低时，Ba对致病性Th 17应答的抑制作用在很大程度上被消除。综上所述，我们的研究结果表明，Ba作为一种新型抗炎剂具有治疗自身免疫性疾病（如MS）的巨大潜力。
Natural compounds derived from medicinal plants have long been considered a rich source of novel therapeutic agents. Baicalin (Ba) is a bioactive flavonoid compound derived from the root ofScutellaria baicalensis,an herb widely used in traditional medicine for the treatment of various inflammatory diseases. In this study, we investigate the effects and mechanism of action of Ba in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Ba treatment effectively ameliorated clinical disease severity in myelin oligodendrocyte glycoprotein (MOG)35–55 peptide-induced EAE and reduced inflammation and demyelination of the central nervous system (CNS). Ba reduced infiltration of immune cells into the CNS, inhibited expression of proinflammatory molecules and chemokines and prevented Th1 and Th17 cell differentiation via STAT/NFκB signaling pathways. Further, we showed that SOCS3 induction is essential to the effects of Ba, given that the inhibitory effect of Ba on pathogenic Th17 responses was largely abolished when SOCS3 signaling was knocked down. Taken together, our findings demonstrate that Ba has significant potential as a novel anti-inflammatory agent for therapy of autoimmune diseases such as MS.