The autologous mixed lymphocyte reaction in primary biliary cirrhosis: Analysis of activation and blastogenesis of autoreactive T lymphocytes
The autologous mixed lymphocyte reaction in primary biliary cirrhosis: Analysis of activation and blastogenesis of autoreactive T lymphocytes
复制标题
原发性胆汁性肝硬化的自体混合淋巴细胞反应：自身反应性T淋巴细胞的活化和胚细胞发生分析
DOI：
10.1002/hep.1840080614
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发表时间：
1988
期刊：
影响因子：
13.5
通讯作者：
H. Homburger
中科院分区：
文献类型：
--
作者：
K. Lindor;R. Wiesner;E. Dickson;H. Homburger
Blastogenesis of autoreactive T lymphocytes in the autologous mixed lymphocyte reaction has been shown to be decreased in patients with primary biliary cirrhosis, but the mechanisms underlying this abnormality are not known. To investigate further the abnormal autologous mixed lymphocyte reaction in primary biliary cirrhosis, we measured the activation of autoreactive helper/inducer and suppressor/cytotoxic T lymphocytes concurrently with blastogenesis in 35 patients with primary biliary cirrhosis and 18 healthy controls. Blastogenesis was diminished in autologous mixed lymphocyte reaction cultures from primary biliary cirrhosis patients compared to the control subjects (25,273 ± 20,259 dpm vs. 36,004 ± 14,951 dpm, p < 0.02), but cultures from patients with primary biliary cirrhosis contained significantly increased percentages of activated helper/inducer and suppressor/cytotoxic T lymphocytes: 20.6 ± 7.9 vs. 15.5 ± 5.3%, p < 0.008, and 9.8 ± 7.8 vs. 5.4 ± 3.0%, p < 0.02, respectively. These findings were not related to the histologic stage of liver disease or to the serum bilirubin concentration and were not associated with abnormalities of lymphocyte subsets in fresh peripheral blood specimens. We conclude that the percentage of autoreactive T lymphocytes in autologous mixed lymphocyte reaction cultures from peripheral blood is increased in patients with primary biliary cirrhosis and diminished blastogenesis in autologous mixed lymphocyte reaction cultures is not due to the loss of autoreactive T lymphocytes from peripheral blood. Diminished blastogenesis reflects a diminished proliferative response of activated, autoreactive T lymphocytes in primary biliary cirrhosis. Possible mechanisms that may account for the paradoxical findings of decreased blastogenesis and increased activation of autoreactive T lymphocytes in primary biliary cirrhosis are discussed.
自体混合淋巴细胞反应中参与自我识别和 T 细胞激活的表面分子。
DOI：
--
发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Romain,PL;Schlossman,SF;Reinherz,EL
通讯作者：
Reinherz,EL
原发性胆汁性肝硬化体外单核细胞调节异常。
DOI：
10.1111/j.1600-0676.1981.tb00037.x
发表时间：
1981
期刊：
Liver
影响因子：
--
作者：
Dienstag,JL;Weake,JR;Wands,JR
通讯作者：
Wands,JR