Reported family history of cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
Reported family history of cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
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DOI：
10.1093/aje/kwg043
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发表时间：
2003-05-01
影响因子：
5
通讯作者：
Buys, S
中科院分区：
文献类型：
--
作者：
Pinsky, PF;Kramer, BS;Buys, S
作者分析了在前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中登记的近15万名年龄在55-74岁之间的受试者的数据，这些受试者完成了一份自我管理的基线问卷(1993-2001年)，其中包括癌症家族史的项目。男性受访者报告的癌症家族史明显少于女性。男性受访者相对于女性的相对漏报比例，女性家庭成员(姐妹低28%，母亲低21%)高于男性家庭成员(兄弟低13%，父亲低9%)。黑人、西班牙裔和亚裔受访者报告的癌症家族史明显少于白人。据报道，父母的家族史患病率随着受访者的年龄而下降，而兄弟姐妹的家族史患病率随着受访者的年龄而上升。家庭中最常见的四种癌症是乳腺癌(11.8%)、肺癌(10.1%)、结直肠癌(9.4%)和前列腺癌(7.3%)。使用从监测、流行病学和最终结果计划获得的发病率和生命表数据，计算总体癌症病史和特定类型癌症病史的家庭成员的预期患病率。总体而言，家庭成员报告的癌症发病率与预期癌症发病率的比率约为0.7。报告的肝癌、骨癌、胃癌和脑癌的比率高于平均水平，而淋巴瘤、膀胱癌、黑色素瘤和睾丸癌的比率低于平均水平。
The authors analyzed data from almost 150,000 subjects aged 55-74 years enrolled in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial who completed a self-administered baseline questionnaire (1993-2001) that included items about family history of cancer. Male respondents reported significantly less family history of cancer than females. The relative underreporting by male respondents relative to females was greater for female family members (28% lower for sisters and 21% lower for mothers) than for male family members (13% lower for brothers and 9% lower for fathers). Black, Hispanic, and Asian respondents reported significantly less family history of cancer than Whites. Reported family history prevalences for parents decreased with respondents' age, while those for siblings increased with respondents' age. The four most commonly reported cancers in families were breast (11.8%), lung (10.1%), colorectal (9.4%), and prostate (7.3%) cancer. Expected prevalences in family members of history of cancer overall and history of specific types of cancer were calculated using incidence rates and life table data obtained from the Surveillance, Epidemiology, and End Results Program. Overall, the ratio of reported cancer rates to expected cancer rates in family members was approximately 0.7. Liver, bone, stomach, and brain cancer had greater-than-average reported:expected ratios, while lymphoma, bladder cancer, melanoma, and testicular cancer had lower-than-average ratios.