Early endotoxic shock results in enhanced vasodilator responses to nitroglycerin but unaltered responses to neuropeptides calcitonin gene-related peptide and substance P.
Early endotoxic shock results in enhanced vasodilator responses to nitroglycerin but unaltered responses to neuropeptides calcitonin gene-related peptide and substance P.
复制标题
早期内毒素休克导致血管舒张剂对硝酸甘油的反应增强，但对神经肽、降钙素基因相关肽和 P 物质的反应未改变。
DOI：
10.1097/00024382-199406000-00006
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Gross,DR
中科院分区：
文献类型：
--
作者：
Arden,WA;Fiscus,RR;Wang,X;Maley,R;Lanzo,S;Gross,DR
要确定的作用，血管活性神经肽，降钙素基因相关肽，P物质发挥组织血流调节在早期感染性休克，我们检查了反应性的动脉从猪3小时后，大肠杆菌脂多糖或生理盐水的车辆。切除颈动脉、肠系膜前动脉和冠状动脉左前降支，并从每条血管上切下环。对累积剂量的去甲肾上腺素或氯化钾获得收缩反应。环重建和挑战与乙酰胆碱，P物质，降钙素基因相关肽，硝酸甘油。脂多糖显著增加肠系膜前动脉对高浓度去甲肾上腺素的反应和对硝酸甘油的反应。这种对硝酸甘油反应的增强表明平滑肌对外源性一氧化氮的反应性增强，可能与基础内皮功能的早期抑制有关。抑制激动剂诱导的一氧化氮释放可能会掩盖这种增强内皮依赖性扩张剂，并可能会提高一些血管床肾上腺素能收缩剂的反应。
To determine the role that vasoactive neuropeptides, calcitonin gene-related peptide, and substance P play in tissue-blood flow regulation during early septic shock, we examined the responsiveness of arteries removed from pigs 3 h after administration of Escherichia coli lipopolysaccharide or saline vehicle. The carotid, cranial mesenteric, and left anterior descending coronary arteries were excised, and rings were cut from each vessel. Constrictor responses were obtained to cumulative doses of norepinephrine or potassium chloride. Rings were reconstricted and challenged with acetylcholine, substance P, calcitonin gene-related peptide, and nitroglycerin. Lipopolysaccharide significantly increased the cranial mesenteric artery's response to high concentrations of norepinephrine and the response to nitroglycerin in all vessels. This enhancement of responses to nitroglycerin suggests augmented smooth-muscle responsiveness to an exogenous source of nitric oxide, possibly associated with early depression of basal endothelial function. Depression of agonist-induced nitric oxide release may mask such enhancement with endothelial-dependent dilators and may enhance the response to adrenergic constrictors in some vascular beds.