EMOTIONAL HYPOTHERMIA IN RABBITS
EMOTIONAL HYPOTHERMIA IN RABBITS
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DOI：
10.1152/ajplegacy.1950.160.2.285
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发表时间：
1950-01-01
影响因子：
--
通讯作者：
GRANT, R
中科院分区：
文献类型：
--
作者：
GRANT, R
将正常姿势的兔子囚禁在一个松散的铁丝网笼中，会导致体温过低，有时会超过2.5℃，甚至一个陌生的环境也会导致体温过低。这种效果是由于热损失机制的矛盾激活（呼吸急促，耳部血管舒张）。冷却通常会在稍后逆转，但需要几个小时。可能在正常温度恢复之前发生，或者根本无法恢复。摄氧量不受抑制，但寒颤不存在，而热损失机制是活跃的。如果兔在约束前和约束期间暴露在寒冷（4[度]C）中，则不会发生冷却。热原质injns。但即使在恢复正常体温后注射，受约束的家兔也没有出现随之而来的发热。这种效果归因于体温调节中心的“情绪”干扰。建议不限制用于热研究和热原检测的家兔。
Restraint of rabbits in normal posture by enclosure in a loosely-fitting wire mesh cage induces hypothermia, sometimes exceeding 2.5[degree]C, and even a strange environment may cause some hypothermia. The effect is due to paradoxical activation of heat loss mechanisms (polypnea, ear vasodilation). Cooling is usually later reversed, but several hrs. may elapse before normal temp. is restored, or restoration may not occur at all. Oxygen uptake is not depressed, but shivering is absent, while heat loss mechanisms are active. Cooling does not occur if the rabbit is exposed to cold (4[degree]C) before and during restraint. Pyrogen injns. interrupt cooling, but consequent fever is not shown by restrained rabbits even when injected after recovery of normal temp. The effect is attributed to "emotional" disturbance of thermoregulatory centers. It is recommended that rabbits used for thermal studies and pyrogen testing should not be restrained.