Azumamides A-E:: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis
Azumamides A-E:: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis
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DOI：
10.1002/anie.200602047
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Fusetani, Nobuhiro
中科院分区：
文献类型：
--
作者：
Nakao, Yoichi;Yoshida, Satoru;Fusetani, Nobuhiro
组蛋白乙酰化和脱乙酰化分别由组蛋白乙酰转移酶 (HAT) 和组蛋白脱乙酰酶 (HDAC) 催化，在转录调控中发挥重要作用。 [1]这些酶的抑制剂可诱导细胞周期停滞，[2] 不依赖于 p53 诱导细胞周期蛋白依赖性激酶抑制剂 p21，[3] 肿瘤选择性细胞凋亡，[4] 以及正常细胞和恶性细胞的分化。 [5]最近，HDAC 抑制剂如曲古抑菌素 A (TSA) 和辛二酰苯胺异羟肟酸 (SAHA) 被证明可以通过改变血管内皮生长因子信号传导发挥有效的抗血管生成作用。 [6]这些直接和
Histone acetylation and deacetylation, which are catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively, play important roles in transcriptional regulation.[1] Inhibitors of these enzymes induce cell-cycle arrest,[2] p53-independent induction of the cyclin-dependent kinase inhibitor p21,[3] tumor-selective apoptosis,[4] and differentiation of normal and malignant cells.[5] Recently, HDAC inhibitors such as trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA) were demonstrated to exert potent anti-angiogenic effects through the alteration of vascular endothelial growth factor signaling.[6] These direct and