Expression of c-fos precedes MDR3 in vincristine and adriamycin selected multidrug resistant murine erythroleukemia cells.
Expression of c-fos precedes MDR3 in vincristine and adriamycin selected multidrug resistant murine erythroleukemia cells.
复制标题
在长春新碱和阿霉素选择的多重耐药小鼠红白血病细胞中，c-fos 的表达先于 MDR3。
DOI：
10.1006/bbrc.1996.1434
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发表时间：
1996
影响因子：
3.1
通讯作者：
Tritton,TR
中科院分区：
文献类型：
--
作者：
Bhushan,A;Slapak,CA;Levy,SB;Tritton,TR
由mdr 1 ormdri 3编码的鼠P-糖蛋白（P-gp）的表达赋予多药耐药表型。c-fos和c-jun在多药耐药的人和鼠细胞中也有较高的表达。我们检测到c-fosearly在两个系列的小鼠红白血病亚系中的表达增加，这些亚系选择对长春新碱或阿霉素耐药，最终过表达mdr 3。我们推测c-fosearly的表达使细胞过表达其他基因，如mdr 3，导致多药耐药表型。
Expression of murine P-glycoprotein (P-gp), encoded bymdr1ormdri3,confers a multidrug resistance phenotype. Higher expression ofc-fosandc-junhas also been demonstrated in multidrug resistant human and murine cells. We detected increased expression ofc-fosearly in the derivation of two series of murine erythroleukemia sublines selected for resistance to vincristine or adriamycin which eventually overexpressmdr3.We speculate that early expression ofc-fosprepares cells for overexpression of other genes, such asmdr3,that contribute to the multidrug resistance phenotype.