Genomic Exploration of the Hemiascomycetous Yeasts:: 18.: Comparative analysis of chromosome maps and synteny with Saccharomyces cerevisiae
Genomic Exploration of the Hemiascomycetous Yeasts:: 18.: Comparative analysis of chromosome maps and synteny with Saccharomyces cerevisiae
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DOI：
10.1016/s0014-5793(00)02289-4
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发表时间：
2000-12-22
期刊：
影响因子：
3.5
通讯作者：
Dujon, B
中科院分区：
文献类型：
--
作者：
Llorente, B;Malpertuy, A;Dujon, B
我们通过将本计划中部分测序的13种酵母菌的基因顺序和方向与酿酒酵母的基因组图谱进行比较，分析了半囊菌染色体图谱的进化。通过分析近8000种情况，其中两个不同的基因在S.cerebralae中具有同源物，可以在另一个东方物种的测序插入物上鉴定，我们量化了同线性的丢失，单基因缺失的频率和基因倒位的发生。通过与其他物种的比较，可以确定S.cerebralae基因组中祖先重复的痕迹，这些痕迹与S.cerebralae的比较不完全一致。certainly与自己从这样的重复和从观察到的基因倒位和同线性丧失之间的相关性，提出了半子囊菌的分子进化模型，该模型，这可能是扩展到其他真核生物，是基于重复的染色体片段的事件，创建瞬时merodiploids，随后由单基因缺失事件解决。(C)2000年欧洲生物化学学会联合会。由Elsevier Science B.V.出版，版权所有。
We have analyzed the evolution of chromosome maps of Hemiascomycetes by comparing gene order and orientation of the 13 yeast species partially sequenced in this program with the genome map of Saccharomyces cervisiae. From the analysis of nearly 8000 situations in which two distinct genes having homologs in S.cervisiae could be identified on the sequenced inserts of another east species, we have quantified the loss of synteny, the frequency of single gene deletion and the occurrence of gene inversion. Traces of ancestral duplications in the genome of S.cervisiae could be identified from the comparison with the other species that do not entirely coincide with those identified from the comparison of S. cervisiae with itself. From such duplications and from the correlation observed between gene inversion and loss of synteny, a model is proposed for the molecular evolution of Hemiascomycetes, This model, which can possibly be extended to other eukaryotes, is based on the reiteration of events of duplication of chromosome segments, creating transient merodiploids that are subsequently resolved by single gene deletion events. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.