The fatty acid compositions of erythrocyte and plasma polar lipids in children with autism, developmental delay or typically developing controls and the effect of fish oil intake
The fatty acid compositions of erythrocyte and plasma polar lipids in children with autism, developmental delay or typically developing controls and the effect of fish oil intake
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DOI：
10.1017/s0007114509992881
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发表时间：
2010-04-28
影响因子：
3.6
通讯作者：
O'Hare, Anne E.
中科院分区：
文献类型：
--
作者：
Bell, John Gordon;Miller, Deborah;O'Hare, Anne E.
在一项病例对照研究中，将自闭症儿童的红细胞和血浆脂肪酸组成与典型发育（TD）儿童和发育迟缓（DD）儿童进行了比较。45名自闭症受试者与TD对照组年龄匹配，38名与DD对照组年龄匹配。使用配对t检验比较脂肪酸数据。此外，通过双样本t检验比较了未接受过治疗的自闭症受试者与服用鱼油补充剂的自闭症受试者的血液脂肪酸。自闭症和TD受试者的红细胞脂肪酸之间的差异相对较小，尽管前者的花生四烯酸（ARA）：EPA比例增加。在同一儿童的血浆样本中，这一比例也有所增加。当将自闭症与DD受试者进行比较时，未观察到n-3脂肪酸或ARA：EPA比率的变化，但DD受试者中的一些SFA和MUFA降低，最明显的是24：0和24：1，这是轴突髓鞘的基本成分。然而，如果考虑多重比较，并应用更严格的显著性水平，则这些值中的大多数将不显著。食用鱼油的自闭症受试者显示红细胞ARA、22：4 n-6、22：5 n-6和总n-6脂肪酸减少，EPA、22：5 n-3、22：6 n-3和总n-3脂肪酸增加，同时沿着n-6：n-3和ARA：EPA比率减少。总的来说，自闭症受试者没有潜在的磷脂紊乱，红细胞脂肪酸组成的基础上，虽然增加ARA：EPA的比例观察表明，一个不平衡的必需高度不饱和脂肪酸可能存在于自闭症受试者的队列。
The erythrocyte and plasma fatty acid compositions of children with autism were compared in a case-control study with typically developing (TD) children and with children showing developmental delay (DD). Forty-five autism subjects were age-matched with TD controls and thirty-eight with DD controls. Fatty acid data were compared using paired t tests. In addition, blood fatty acids from treatment-naive autism subjects were compared with autism subjects who had consumed fish oil supplements by two-sample t tests. Relatively few differences were seen between erythrocyte fatty acids in autism and TD subjects although the former had an increased arachidonic acid (ARA):EPA ratio. This ratio was also increased in plasma samples from the same children. No changes in n-3 fatty acids or ARA:EPA ratio were seen when comparing autism with DD subjects but some SFA and MUFA were decreased in the DD subjects, most notably 24 : 0 and 24 : 1, which are essential components of axonal myelin sheaths. However, if multiple comparisons are taken into account, and a stricter level of significance applied, most of these values would not be significant. Autism subjects consuming fish oil showed reduced erythrocyte ARA, 22 : 4n-6, 22 : 5n-6 and total n-6 fatty acids and increased EPA, 22 : 5n-3, 22: 6n-3 and total n-3 fatty acids along with reduced n-6:n-3 and ARA:EPA ratios. Collectively, the autism subjects did not have an underlying phospholipid disorder, based on erythrocyte fatty acid compositions, although the increased ARA:EPA ratio observed suggested that an imbalance of essential highly unsaturated fatty acids may be present in a cohort of autism subjects.