Effects of dizocilpine (MK 801) on noradrenaline, serotonin and dopamine release and uptake
Effects of dizocilpine (MK 801) on noradrenaline, serotonin and dopamine release and uptake
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DOI：
10.1097/00001756-200001170-00034
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发表时间：
2000-01-17
期刊：
影响因子：
1.7
通讯作者：
Stamford, JA
中科院分区：
文献类型：
--
作者：
Callado, LF;Hopwood, SE;Stamford, JA
在本研究中，我们用快速循环伏安法（FCV）检测了NMDA拮抗剂二唑西平（MK801）对大鼠脑片蓝斑（LC）中去甲肾上腺素（NA）、中隔背核（DRN）中血清素（5-HT）和伏隔核（NAc）中多巴胺（DA）的电诱发释放和摄取的作用。地唑西平（10亩M）显著提高了NA（248 +/- 15%）和5-羟色胺释放（184+/-29%），减缓了LC （t(1/2)=853+/-129%）和DRN （t(1/2)=387+/-70%）的单胺摄取。然而，二唑西平对NAc中DA的释放和摄取没有影响。因此，对单胺类药物的作用是可能的，在解释有关二唑西平的数据时应予以考虑。《神经病学报告》（英文版），2011年第11期。
In the present study, we examined the actions of the NMDA antagonist dizocilpine (MK801) on electrically evoked release and uptake of noradrenaline (NA) in the locus coeruleus (LC), serotonin (5-HT) in the dorsal raphe nucleus (DRN) and dopamine (DA) in the nucleus accumbens (NAc), measured by fast cyclic voltammetry (FCV) in rat brain slices. Dizocilpine (10 mu M) significantly increased NA (to 248 +/- 15%) and 5-HT release (to 184+/-29%) and slowed monoamine uptake in the LC (t(1/2)=853+/-129%) and the DRN (t(1/2)=387+/-70%), respectively. However, dizocilpine had no effect on DA release or uptake in NAc. Actions on monoamines are thus likely and should be considered in the interpretation of data regarding dizocilpine. NeuroReport 11:173-176 (C) 2000 Lippincott Williams & Wilkins.