Combined Raman spectroscopy and optical coherence tomography device for tissue characterization
Combined Raman spectroscopy and optical coherence tomography device for tissue characterization
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DOI：
10.1364/ol.33.001135
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发表时间：
2008-05-15
期刊：
影响因子：
3.6
通讯作者：
Mahadevan-Jansen, Anita
中科院分区：
文献类型：
--
作者：
Patil, Chetan A.;Bosschaart, Nienke;Mahadevan-Jansen, Anita
We report a dual-modal device capable of sequential acquisition of Raman spectroscopy (RS) and optical coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab. (C) 2008 Optical Society of America.
