Electrophysiological Responses in the Ventral Temporal Cortex During Reading of Numerals and Calculation
Electrophysiological Responses in the Ventral Temporal Cortex During Reading of Numerals and Calculation
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DOI：
10.1093/cercor/bhv250
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发表时间：
2017-01-01
期刊：
影响因子：
3.7
通讯作者：
Parvizi, Josef
中科院分区：
文献类型：
--
作者：
Hermes, Dora;Rangarajan, Vinitha;Parvizi, Josef
最近的证据表明，特定的神经元群体在腹侧颞叶皮层显示更大的电生理反应的视觉数字相比，形态相似的刺激。本研究探讨这些反应如何从简单的阅读数字的算术上下文中的积极使用数字的变化。我们记录了高频宽带（HFB）信号，这是局部神经元群体活动的可靠测量方法，而10名植入硬膜下电极的癫痫患者执行了单独的数字阅读和计算任务。我们发现，计算增加了后颞下回（ITG）的活动，在计算的前500毫秒内增加了约1.5倍，而没有计算或阅读和判断记忆语句的阅读数字则没有增加。在2个相同受试者中进行的第二个实验中，我们表明，当在计算环境中连续呈现单个数字时，HFB反应以系统的方式增加：ITG中的HFB反应，对第二和第三个数字（即，在a + B = c）中的B和c的反应比对第一个数字（a）的反应大大约1.5倍。这些结果提供了电生理证据调制的局部神经元群体的视觉刺激的基础上不断增加的任务需求的反应。
Recent evidence suggests that specific neuronal populations in the ventral temporal cortex show larger electrophysiological responses to visual numerals compared with morphologically similar stimuli. This study investigates how these responses change from simple reading of numerals to the active use of numerals in an arithmetic context. We recorded high-frequency broadband (HFB) signals, a reliable measure for local neuronal population activity, while 10 epilepsy patients implanted with subdural electrodes performed separate numeral reading and calculation tasks. We found that calculation increased activity in the posterior inferior temporal gyrus (ITG) with a factor of approximately 1.5 over the first 500 ms of calculation, whereas no such increase was noted for reading numerals without calculation or reading and judging memory statements. In a second experiment conducted in 2 of the same subjects, we show that HFB responses increase in a systematic manner when the single numerals were presented successively in a calculation context: The HFB response in the ITG, to the second and third numerals (i.e., b and c in a + b = c), was approximately 1.5 times larger than the responses to the first numeral (a). These results provide electrophysiological evidence for modulation of local neuronal population responses to visual stimuli based on increasing task demands.