Transmission dynamics of rabies in China over the last 40 years: 1969-2009
Transmission dynamics of rabies in China over the last 40 years: 1969-2009
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DOI：
10.1016/j.jcv.2010.06.014
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发表时间：
2010-09-01
影响因子：
8.8
通讯作者：
Rupprecht, Charles E.
中科院分区：
文献类型：
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作者：
Meng, Shengli;Xu, Gelin;Rupprecht, Charles E.
背景：狂犬病是我国一种严重的人畜共患病。从历史资料中推断狂犬病毒的分子进化和传播模式，可以为今后更好的疾病控制和预防提供指导。目的：调查狂犬病毒在中国的流行病学和进化动力学。1969 - 2000年我国17省3市132株狂犬病毒糖蛋白基因序列的分子进化分析结果：系统发育分析表明，中国狂犬病病毒在狂犬病病毒基因1型内可分为6个谱系（A-F）。谱系A代表广泛分布的世界性谱系，而谱系B与北极样狂犬病病毒密切相关。其余的血统（C-F）是在东南亚大部分地区流传的典型血统。中国狂犬病病毒的进化速率为1.532 × 10（-4）/位点/年，对应的共同祖先约为1115个。结论：中国狂犬病病毒的地理分布格局表明，由于人类活动的影响，中国狂犬病病毒存在省内和省外传播。(C)2010年爱思唯尔B。V.保留所有权利。
Background: Rabies is a serious reemerging zoonosis in China. The molecular evolution and transmission patterns of rabies virus inferred from historical data can provide guidelines for better disease control and prevention in the future.Objectives: To investigate the epidemiology and evolutionary dynamics of the rabies virus in China.Study design: The molecular evolution of 132 viral glycoprotein gene sequences of Chinese rabies viruses collected in 17 provinces and 3 municipalities between 1969 and 2009 was analyzed.Results: Phylogenetic analysis revealed that Chinese rabies viruses are subdivided into 6 lineages (A-F) within Lyssavirus genotype 1. Lineage A represents the widely dispersed cosmopolitan lineage while lineage B is closely related to Arctic-like rabies viruses. The remaining lineages (C-F) are typical of those circulating across much of Southeast Asia. The evolutionary rate for Chinese rabies virus was 1.532 x 10(-4) substitutions per site per year, and the corresponding common ancestor was in about 1115.Conclusions: The phylogeographic structure demonstrated Chinese rabies viruses have been transmitted intra-provincially and extra-provincially due to human-related activities. (C) 2010 Elsevier B. V. All rights reserved.