Prognostic value of natriuretic peptides in Chagas' disease: A 3-year follow-up investigation
Prognostic value of natriuretic peptides in Chagas' disease: A 3-year follow-up investigation
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DOI：
10.1159/000112403
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发表时间：
2008-01-01
期刊：
影响因子：
1.9
通讯作者：
Walther, Thomas
中科院分区：
文献类型：
--
作者：
Moreira, Maria da Consolacao V.;Heringer-Walther, Silvia;Walther, Thomas
背景：恰加斯病影响拉丁美洲约1800万人。为了确定利钠肽在CD患者中的诊断和预后价值，我们测量了心房（ANP）和脑利钠肽（BNP），并将其与其他扩张型心肌病（DCM）的结果进行了比较。方法：采集111例CD患者、62例其他原因DCM患者和43例性别和年龄匹配的健康受试者的血液样本。根据NYHA分类对CD和DCM患者进行细分。用免疫放射测定法测定利钠肽浓度。结果：与NYHA分类相比，CD和DCM患者ANP和BNP水平明显升高。NYHA I-II级CD患者的循环BNP浓度高于相应的DCM患者（p = 0.020）。重要的是，在没有收缩期心室功能障碍的CD患者中，ANP和BNP已经显著升高
Background: Chagas' disease (CD) affects around 18 million people in Latin America. To determine the diagnostic and prognostic value of natriuretic peptides in patients with CD, we measured atrial (ANP) and brain natriuretic peptide (BNP), and compared the findings with other dilated cardiomyopathies (DCM). Methods: Blood samples were obtained from 111 CD patients, 62 patients with DCM due to other causes, and 43 gender- and age-matched healthy subjects. The CD and DCM patients were subdivided according to their NYHA classification. Natriuretic peptide concentrations were determined by immunoradiometric assays. Results: ANP and more pronounced BNP levels were increased in CD and DCM patients in relation to the NYHA class. Circulating BNP concentrations were higher in CD patients in NYHA classes I-II than in the corresponding DCM patients (p = 0.020). Importantly, ANP and BNP were already significantly elevated in CD patients without systolic ventricular dysfunction (p