Tobacco use outcomes among patients with head and neck carcinoma treated for nicotine dependence - A matched-pair analysis
Tobacco use outcomes among patients with head and neck carcinoma treated for nicotine dependence - A matched-pair analysis
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DOI：
10.1002/cncr.20350
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发表时间：
2004-07-01
期刊：
影响因子：
6.2
通讯作者：
Hurt, RD
中科院分区：
文献类型：
--
作者：
Garces, YI;Schroeder, DR;Hurt, RD
背景。当前的研究描述了在梅奥诊所尼古丁依赖中心（NDC；明尼苏达州罗切斯特）接受尼古丁依赖治疗的头颈癌患者的烟草使用结果。方法。采用 1:1 配对设计，采用条件逻辑回归来比较 1988 年至 2001 年间接受尼古丁依赖治疗的一般患者群体中头颈癌患者 (n = 101) 和对照组 (n = 101) 6 个月戒烟结果。两组在年龄、性别、治疗日期和 NDC 治疗服务类型方面进行匹配。 结果。两组之间的基线人口统计数据相似。然而，头颈癌患者每天吸烟量 (cpd) 明显多于对照组 (P = 0.003)。头颈癌患者在 6 个月随访时自我报告的戒烟率为 33%，而匹配对照组为 26%（P = 0.279；调整基线 cpd 和变化阶段后，P = 0.205）。在头颈癌患者中，诊断后 3 个月内、3 个月至 5 年内、5 年以上接受 NDC 咨询的患者的戒烟率分别为 47%、22% 和 19%（P = 0.021）。此外，在诊断后 3 个月内接受手术（有或没有放射治疗）的头颈癌患者比接受初次放射治疗的患者更有可能戒烟（P = 0.042）。结论。这些发现表明，尼古丁依赖治疗对头颈癌患者有效，特别是在初次诊断后不久以及接受手术作为主要治疗的患者中。 (C) 2004 年美国癌症协会。
BACKGROUND. The current study described tobacco use outcomes among patients with head and neck carcinoma who underwent treatment for nicotine dependence at the Mayo Clinic Nicotine Dependence Center (NDC; Rochester, MN).METHODS. Using a 1:1 matched-pair design, conditional logistic regression was employed to compare the 6-month tobacco abstinence outcomes of patients with head and neck carcinoma (n = 101) with controls (n = 101) from the general patient population treated for nicotine dependence between 1988 and 2001. The two groups were matched with regard to age, gender, date of treatment, and type of NDC treatment service.RESULTS. Baseline demographics were similar between both groups. However, patients with head and neck carcinoma smoked significantly more cigarettes per day (cpd) than controls (P = 0.003). The self-reported tobacco abstinence rate at the 6-month follow-up was 33% for patients with head and neck carcinoma compared with 26% for matched controls (P = 0.279; after adjusting for baseline cpd and stage of change, P = 0.205). Among patients with head and neck carcinoma, the tobacco abstinence rates were 47%, 22%, and 19%, respectively, for those receiving an NDC consult within 3 months, between 3 months and 5 years, and > 5 years after their diagnosis (P = 0.021). Furthermore, the patients with head and neck carcinoma treated within 3 months of diagnosis who received surgery (with or without radiation therapy) were more likely to be tobacco abstinent than those who received primary radiation therapy (P = 0.042).CONCLUSIONS. These findings suggested that nicotine dependence treatments were effective among patients with head and neck carcinoma, particularly when delivered shortly after initial diagnosis and for those who received surgery as their primary treatment. (C) 2004 American Cancer Society.