Evolution of Olfactory Disorders inCOVID-19 Patients
Evolution of Olfactory Disorders inCOVID-19 Patients
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DOI：
10.1002/lary.28957
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发表时间：
2020-08-05
期刊：
影响因子：
2.6
通讯作者：
Duc Trung Nguyen
中科院分区：
文献类型：
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作者：
Gorzkowski, Victor;Bevilacqua, Sibylle;Duc Trung Nguyen
目的据报道，嗅觉/味觉障碍与COVID-19的发生频率很高，且有很强的相关性。它的自发演化仍然未知。本研究的目的是调查COVID-19患者嗅觉障碍的自发演变。研究设计横断面研究。方法纳入2020年3月1日至31日在我院接受实验室确诊的229例COVID-19患者。其中，140名患者（平均年龄38.5岁，89名女性）报告了COVID-19期间突发的嗅觉/味觉障碍。在调查时，所有患者都通过电话进行了问卷调查，其中包括16个问题。主要终点是调查时的嗅觉恢复率。结果2020年3月20日之前嗅觉障碍患者的频率高于此后（分别为70.3%和53.9%）（P= 0.016）。在调查时（平均26天，从嗅觉丧失发作），95.71%的报告开始嗅觉恢复。从嗅觉丧失开始到恢复开始的平均时间为11.6天。78.4%的患者在嗅觉丧失发作后第4 ~ 15天开始恢复。51.43%的患者嗅觉完全恢复。在COVID-19患者中，嗅觉完全恢复与嗅觉丧失发作至恢复发作的时间短（P= 0.0004）、无鼻塞（P= 0.023）和无鼻子疼痛/干燥/刺痛感（P= 0.007）之间存在显著相关性。结论了解嗅觉障碍的自发性演变，可以让患者放心，并为COVID-19明确康复后的持续性嗅觉功能障碍制定治疗策略。证据等级4喉镜，2020年
Objectives A high frequency and a strong association of olfactory/gustatory impairment with COVID-19 were reported. Its spontaneous evolution remains unknown. The aim of this study was to investigate the spontaneous evolution of olfactory disorders in COVID-19 patients. Study Design Cross-sectional study. Methods A total of 229 patients with laboratory-confirmed COVID-19 from March 1 through 31, 2020 in our institution were included. Among them, 140 patients (mean age, 38.5 years, 89 women) reported sudden olfactory/gustatory disorders during COVID-19. All patients were interviewed by phone based on a questionnaire with 16 questions at time of survey. The primary end point was olfactory recovery rate at time of survey. Results The frequency of patients with olfactory disorders was higher before March 20, 2020 than since (70.3% vs. 53.9%, respectively) (P= .016). At time of survey (26 days of the mean time from anosmia onset), 95.71% reported to start an olfactory recovery. The mean time from olfactory loss onset to recovery onset was 11.6 days. Recovery started between the fourth and the fifteenth day after olfactory loss onset in 78.4% of patients. Complete olfactory recovery happened for 51.43% of patients. There was a significant relationship between the complete olfactory recovery and a short time from olfactory loss onset to recovery onset (P= .0004), absence of nasal obstruction (P= .023) and absence of sore/dry/tingling feeling in the nose (P= .007) in COVID-19 patients. Conclusion Knowledge of spontaneous evolution of olfactory disorders allows reassuring patients and planning therapeutic strategies for persistent olfactory dysfunction after having definitely recovered from COVID-19. Level of Evidence 4Laryngoscope, 2020