Fluid-structure coupled biotransport processes in aortic valve disease
Fluid-structure coupled biotransport processes in aortic valve disease
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DOI：
10.1016/j.jbiomech.2021.110239
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发表时间：
2021-01-27
影响因子：
2.4
通讯作者：
Arzani, Amirhossein
中科院分区：
文献类型：
--
作者：
Sadrabadi, Mohammadreza Soltany;Hedayat, Mohammadali;Arzani, Amirhossein
主动脉瓣附近的生物转运过程在钙化性主动脉瓣疾病的发生和生物瓣膜血栓形成中起着至关重要的作用。血流动力学加上小叶的动力学，调节着这些运输模式。本文对二维二尖瓣和三维机械瓣膜进行了双向流固耦合相互作用(FSI)模拟，并与各种描述钙化和血栓形成过程的对流传质模型相耦合。也就是说，开发了五种不同的连续传输模型来研究源自血液和小叶的生物化学物质，以及停留时间和流动停滞。分别研究了低密度脂蛋白(LDL)和血小板活化在钙化和血栓形成中的作用。用涡度和拉格朗日相干结构(LCS)分别识别二维和三维模型的相干结构。旋涡结构与生化浓度型之间存在着非常密切的联系，不同的旋涡根据输送机制控制着浓度型。此外，还揭示了小叶浓度与壁面剪应力之间的关系。我们的工作表明，血流物理和相干结构调节血流介导的生物过程，涉及主动脉瓣钙化和血栓形成，因此可以用于设计过程，以优化心脏瓣膜置换的耐久性。(C)2021年爱思唯尔有限公司。保留所有权利。
Biological transport processes near the aortic valve play a crucial role in calcific aortic valve disease initiation and bioprosthetic aortic valve thrombosis. Hemodynamics coupled with the dynamics of the leaflets regulate these transport patterns. Herein, two-way coupled fluid-structure interaction (FSI) simulations of a 2D bicuspid aortic valve and a 3D mechanical heart valve were performed and coupled with various convective mass transport models that represent some of the transport processes in calcification and thrombosis. Namely, five different continuum transport models were developed to study biochemicals that originate from the blood and the leaflets, as well as residence-time and flow stagnation. Low-density lipoprotein (LDL) and platelet activation were studied for their role in calcification and thrombosis, respectively. Coherent structures were identified using vorticity and Lagrangian coherent structures (LCS) for the 2D and 3D models, respectively. A very close connection between vortex structures and biochemical concentration patterns was shown where different vortices controlled the concentration patterns depending on the transport mechanism. Additionally, the relationship between leaflet concentration and wall shear stress was revealed. Our work shows that blood flow physics and coherent structures regulate the flow-mediated biological processes that are involved in aortic valve calcification and thrombosis, and therefore could be used in the design process to optimize heart valve replacement durability. (c) 2021 Elsevier Ltd. All rights reserved.