Novel methods for quantifying neurophysiologic properties of the human lumbar paraspinal muscles
Novel methods for quantifying neurophysiologic properties of the human lumbar paraspinal muscles
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DOI：
10.1016/j.jneumeth.2010.10.012
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发表时间：
2011-01-15
影响因子：
3
通讯作者：
Clark, Brian C.
中科院分区：
文献类型：
--
作者：
Goss, David A., Jr.;Thomas, James S.;Clark, Brian C.
我们对人类椎旁肌的神经生理学特性的理解一直受到缺乏实验技术来检查这些肌肉在体内功能的阻碍。在这篇文章中，我们描述了一个成对脉冲经颅磁刺激（TMS）协议，以量化皮质内促进（ICF）和短间隔皮质内抑制（SICI）的腰椎旁肌，和机电轻敲协议，以测量短潜伏期牵张反射的振幅。这些协议的重测信度进行了检查，在两个会议间隔30分钟的健康成人。我们通过计算组内相关系数（ICC）评估相对可靠性，通过变异系数（CV）评估绝对可靠性。腰椎旁肌的ICF和SICI表现出在脊椎外骨骼肌中观察到的经典易化和抑制反应（分别类似于30%的易化和抑制）。运动诱发电位振幅（MEP）、ICF、SICI和牵张反射振幅测量值在两次测试中无显著差异（p > 0.05）。MEP波幅、ICF和牵张反射波幅的相对和绝对可靠性最高（ICC = 0.89-0.91，CV = 10.6-11.1%），而SICI的可靠性稍低（ICC = 0.75，CV = 20.1%）。在第一次测试中进行的牵张反射方案不影响第二次测试中的TMS结果测量（p > 0.05）。这些创新的方法可能有助于研究基础生理学，腰痛的病理学以及治疗干预的作用机制。(C)2010 Elsevier BV保留所有权利。
Our understanding the neurophysiologic characteristics of the human paraspinal muscles has historically been hindered by the lack of experimental techniques to examine these muscles function in vivo. In this article we describe a paired-pulse transcranial magnetic stimulation (TMS) protocol to quantify intracortical facilitation (ICF) and short-interval intracortical inhibition (SICI) of the lumbar paraspinal muscles, and an electromechanical tapping protocol to measure the amplitude of the short-latency stretch reflex. Test-retest reliability of these protocols was examined across two sessions separated by 30-min in healthy adults. We assessed relative reliability by calculating the intraclass correlation coefficient (ICC), and absolute reliability was assessed via coefficient of variation (CV). ICF and SICI in the lumbar paraspinal muscles exhibited the classical facilitatory and inhibitory responses observed in appendicular skeletal muscles (similar to 30% facilitation and inhibition, respectively). The motor evoked potential amplitude (MEP), ICF, SICI, and stretch reflex amplitude measurements did not significantly differ between the two testing sessions (p > 0.05). The MEP amplitude, ICF and stretch reflex amplitude exhibited the highest relative and absolute reliability (ICC = 0.89-0.91, CV = 10.6-11.1%); whereas the SICI measure exhibited somewhat lower reliability (ICC = 0.75, CV = 20.1%). The stretch reflex protocol performed in the first testing session did not influence the TMS outcome measures in the second testing session (p > 0.05). These innovative methods may be useful in studying basic physiology, the pathology of low back pain, as well as the mechanisms of action of treatment interventions. (C) 2010 Elsevier B.V. All rights reserved.