LYMPHOCYTE-DIFFERENTIATING HORMONE OF BURSA OF FABRICIUS
LYMPHOCYTE-DIFFERENTIATING HORMONE OF BURSA OF FABRICIUS
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DOI：
10.1126/science.180600
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发表时间：
1976-01-01
期刊：
影响因子：
56.9
通讯作者：
GOLDSTEIN, G
中科院分区：
文献类型：
--
作者：
BRAND, A;GILMOUR, DG;GOLDSTEIN, G
Induction of early lymphocyte differentiation was studied in vitro in fractionated bone marrow cells of newly hatched chickens, with alloantisera to identify newly differentiated B [bursa-derived] cells (Bu-1+) and T [thymus-derived] cells (Th-1+). Thymus extract induced selective T cell differentiation; the activity of the extract corresponds to that of thymopoietin. Bursal extract induced B cell and T cell differentiation, but at lower concentrations B cell differentiation was always greater. This activity is ascribed to a lymphocyte-differentiating hormone of the bursa of Fabricius, for which the name bursopoietin is suggested.
