A Scalable Protocol for the Regioselective Alkylation of 2-Methylcyclohexane-1,3-dione with Unactivated sp3 Electrophiles.
A Scalable Protocol for the Regioselective Alkylation of 2-Methylcyclohexane-1,3-dione with Unactivated sp3 Electrophiles.
复制标题
用于使用未激活的 sp3 亲电子试剂对 2-甲基环己烷-1,3-二酮进行区域选择性烷基化的可扩展方案。
DOI：
10.1055/s-0035-1560186
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Johnson,JeffreyS
中科院分区：
文献类型：
--
作者：
Sharpe,RobertJ;Portillo,Maribel;Vélez,RobertA;Johnson,JeffreyS
A method for the C-selective alkylation of 2-methylcyclohexane-1,3-dione with unactivated sp3electrophiles is accomplished via alkylation and subsequent deprotection of the derived ketodimethyl hydrazones. The present method provides a high-yielding entry to dialkyl cycloalkanones that cannot be accessed via direct alkylation of 2-methylcyclohexane-1,3-dione. The title reaction may be useful in the scalable preparation of terpene and steroidal building blocks in the arena of natural product synthesis.
