Association between treatment effects on disease progression end points and overall survival in clinical studies of patients with metastatic renal cell carcinoma.
Association between treatment effects on disease progression end points and overall survival in clinical studies of patients with metastatic renal cell carcinoma.
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DOI：
10.1038/bjc.2012.367
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发表时间：
2012-09-25
影响因子：
8.8
通讯作者：
Soulieres, D.
中科院分区：
文献类型：
--
作者：
Delea, T. E.;Khuu, A.;Heng, D. Y. C.;Haas, T.;Soulieres, D.
The relationship between progression-free survival and time to progression (PFS/TTP) and overall survival (OS) has been demonstrated in a variety of solid tumours but not in metastatic renal cell carcinoma (mRCC). A systematic literature search was conducted to identify controlled trials of cytokine or targeted therapies for mRCC reporting information on treatment effects on PFS/TTP and OS for one or more comparison. The associations between treatment effects on PFS/TTP and OS were analysed using linear regression. Thirty-one studies representing 10 943 patients, 75 treatment groups, and 41 comparisons were identified. The correlation coefficient between the negative log of the hazard ratio (HR) for PFS/TTP (−ln HRPFS/TTP) vs the negative log of the HR for OS (−ln HROS) was 0.80 (P<0.0001). In linear regression, the coefficient on −ln HRPFS/TTP vs −ln HROS was 0.64 (95% confidence interval (CI): 0.47 0.81; R2=0.63), suggesting each 10% relative risk reduction (RRR) for PFS/TTP was associated with a 6% RRR for OS. A 1-month gain in median PFS/TTP was associated with a 1.17-month gain in median OS (95% CI: 0.59,1.76; R2=0.28). In trials of treatments for mRCC, treatment effects on PFS/TTP are strongly associated with treatment effects on OS.
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影响因子：
45.3
作者：
Dodd, Lori E.;Korn, Edward L.;Mooney, Margaret M.
通讯作者：
Mooney, Margaret M.
影响因子：
45.3
作者：
Buyse, Marc;Burzykowski, Tomasz;Piedbois, Pascal
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Piedbois, Pascal
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168.9
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Escudier, Bernard;Pluzanska, Anna;Moore, Nicola
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Moore, Nicola
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45.3
作者：
Atkins, MB;Hidalgo, M;Sherman, ML
通讯作者：
Sherman, ML
影响因子：
158.5
作者：
Escudier, Bernard;Eisen, Tim;Bukowski, Ronald M.
通讯作者：
Bukowski, Ronald M.