Generation of polymer nanocapsules via a membrane-extrusion emulsification approach
Generation of polymer nanocapsules via a membrane-extrusion emulsification approach
复制标题
通过膜挤出乳化方法生成聚合物纳米胶囊
DOI：
10.1016/j.matlet.2012.03.004
复制
发表时间：
2012-06-15
影响因子：
3
通讯作者：
Zhu, Jintao
中科院分区：
文献类型：
--
作者：
Xu, Wenjing;Yu, Xi;Zhu, Jintao
我们描述了一种简单、有效的概念，通过膜挤出和自乳化相结合的方法来制备纳米胶囊。首先通过挤出法制备了均匀的含聚合物乳滴，然后在完全去除有机溶剂后得到相对均匀的纳米胶囊。通过改变初始聚合物浓度和挤出通过时间，可以很容易地调整胶囊的尺寸和尺寸分布。这种简便的方法可以扩展到产生不同的可生物降解的聚合物纳米胶囊，这将在药物输送、生物成像和诊断领域找到应用。(C)2012爱思唯尔B.V.保留所有权利。
We describe a simple, effective concept for the fabrication of nanocapsules by combining membrane extrusion and self-emulsification approach. Uniform emulsion droplets containing polymers were firstly prepared through the extrusion strategy, and relatively uniform nanocapsules can thus be generated after complete removal of the organic solvent. Size and size distribution of the capsules can be easily tuned through varying initial polymer concentration and extrusion pass times. This facile approach can be extended to generate different biodegradable polymer nanocapsules which will find applications in the fields of drug delivery, bioimaging, and diagnostics. (C) 2012 Elsevier B.V. All rights reserved.