Ring attractor dynamics in the Drosophila central brain
Ring attractor dynamics in the Drosophila central brain
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DOI：
10.1126/science.aal4835
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发表时间：
2017-05-26
期刊：
影响因子：
56.9
通讯作者：
Jayaraman, Vivek
中科院分区：
文献类型：
--
作者：
Kim, Sung Soo;Rouault, Herve;Jayaraman, Vivek
环形吸引子是一类循环网络，假设它是方向表示的基础。这种网络结构被描绘成一个神经元环，其连通性取决于它们的方向偏好，可以维持一个凹凸状的活动模式，其位置可以通过沿着任何一个转弯方向的连续移动来更新。我们最近报道了一群苍蝇神经元通过凹凸状的活动动态来代表动物的头部。我们将双光子钙成像与光遗传学相结合，将固定头部苍蝇的种群表示覆盖为人工种群表示，然后由自然动态电路维持。一个具有局部激励和全局抑制的网络实现了这种独特而持久的航向表征。环吸引网络在理论工作中一直被引用；我们的研究为它们的存在和功能结构提供了生理证据。
Ring attractors are a class of recurrent networks hypothesized to underlie the representation of heading direction. Such network structures, schematized as a ring of neurons whose connectivity depends on their heading preferences, can sustain a bump-like activity pattern whose location can be updated by continuous shifts along either turn direction. We recently reported that a population of fly neurons represents the animal's heading via bump-like activity dynamics. We combined two-photon calcium imaging in head-fixed flying flies with optogenetics to overwrite the existing population representation with an artificial one, which was then maintained by the circuit with naturalistic dynamics. A network with local excitation and global inhibition enforces this unique and persistent heading representation. Ring attractor networks have long been invoked in theoretical work; our study provides physiological evidence of their existence and functional architecture.