Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome
Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome
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DOI：
10.1016/j.jocn.2003.10.015
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发表时间：
2004-06-01
影响因子：
2
通讯作者：
Simeonova, V
中科院分区：
文献类型：
--
作者：
Alexandrova, M;Bochev, P;Simeonova, V
本文研究了缺血性脑卒中急性期自由基过程的动态变化及其与患者临床状况的关系。重症脑卒中患者在整个急性期外周血吞噬细胞产生活性氧（ROS）的能力增强。这一代与梗死面积、神经功能缺损和残疾的严重程度呈正相关，与患者神经功能状态的改善呈负相关。两种酶的活性增加，从抗氧化防御机制，过氧化氢酶和谷胱甘肽过氧化物酶，登记在整个急性期中风，无论其严重程度。脂质过氧化产物的浓度随时间增加。血中硫代巴比妥酸反应物质（TBARM）浓度与脑梗死面积、神经功能缺损程度及残疾程度呈正相关。总之，吞噬细胞产生的细胞外ROS和血TBARM浓度可作为卒中结局的指标。(C)2003 Elsevier Ltd.保留所有权利。
The dynamics of free radical processes during the acute stage of ischemic stroke and their relationship with the clinical status of patients were studied. An enhanced extracellular generation of reactive oxygen species (ROS) by peripheral phagocytes was observed in severe stroke patients during the whole acute stage. This generation correlated positively with the size of infarct, the severity of neurological deficit and handicap and correlated negatively with the improvement of the neurological status of patients. An increase in the activity of two enzymes from the antioxidant defense mechanism, catalase and glutathione peroxidase, was registered during the whole acute phase of stroke, regardless of its severity. The concentration of lipid peroxidation products increased over time. Blood concentration of thiobarbituric acid-reactive material (TBARM) correlated positively with the size of infarct, the severity of neurological deficit and handicap. In conclusion, extracellular ROS generation by phagocytes and blood TBARM concentration could be used as indicators for stroke outcome. (C) 2003 Elsevier Ltd. All rights reserved.