Dietary vitamin A intake below the recommended daily intake during pregnancy and the risk of congenital diaphragmatic hernia in the offspring
Dietary vitamin A intake below the recommended daily intake during pregnancy and the risk of congenital diaphragmatic hernia in the offspring
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DOI：
10.1002/bdra.23093
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Steegers-Theunissen, Regine P. M.
中科院分区：
文献类型：
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作者：
Beurskens, Leonardus W. J. E.;Schrijver, Lieske H.;Steegers-Theunissen, Regine P. M.
背景维生素A与先天性腹股沟疝（CDH）的病因有关。我们进行了一项病例对照研究，以调查母亲膳食维生素A摄入量是否与后代的CDH有关。方法31例CDH孕妇和46例对照孕妇被纳入研究。CDH诊断和纳入对照组的风险集抽样后，母亲的维生素A摄入量进行了调查的食物频率问卷。测定血清视黄醇和视黄醇结合蛋白。采用单变量和多变量逻辑回归模型计算风险估计值，并对潜在混杂因素进行调整。结果：我们发现病例组和对照组母亲的总体营养素和维生素A摄入量无显著差异。在按体重指数（BMI）分类分层后，体重正常的病例母亲与对照母亲相比，能量调整后的维生素A摄入量较低（685与843 μ g视黄醇活性当量[RAE] /天; p = 0.04），血清视黄醇略低（1.58与1.67 μ mol/L; p = 0.08）。维生素A摄入
BACKGROUND Vitamin A has been related to the etiology of congenital diaphragmatic hernia (CDH). We performed a case-control study to investigate whether maternal dietary vitamin A intake is related to CDH in the offspring. METHODS Thirty-one pregnancies diagnosed with CDH and 46 control pregnancies were included during the study. After CDH diagnosis and inclusion of controls by risk set sampling, maternal vitamin A intake was investigated with a food frequency questionnaire. Serum retinol and retinol-binding protein were determined. Univariable and multivariable logistic regression models were used to calculate risk estimates with adjustment for potential confounders. RESULTS We found no significant differences in the overall nutrient and vitamin A intake between case and control mothers. After stratification in body mass index (BMI) categories, case mothers with normal weight showed a lower energy adjusted vitamin A intake (685 vs. 843 mu g retinol activity equivalents [RAEs] / day; p = 0.04) and a slightly lower serum retinol (1.58 vs. 1.67 mu mol/L; p = 0.08) than control mothers. Vitamin A intake