Naloxone‐insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea‐pig trachea by the novel opioid, nociceptin
Naloxone‐insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea‐pig trachea by the novel opioid, nociceptin
复制标题
新型阿片类药物伤害感受素对支配豚鼠气管的副交感神经释放乙酰胆碱的纳洛酮不敏感抑制
DOI：
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发表时间：
1997
影响因子：
7.3
通讯作者：
M. Belvisi
中科院分区：
文献类型：
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作者：
H. Patel;M. Giembycz;L. Spicuzza;P. J. Barnes;M. Belvisi
μ阿片激动剂[d-ALA2，N-Me-Phe4，Gly5-ol]-脑啡肽(DAMGO)对电刺激诱发的豚鼠气管胆碱能神经释放乙酰胆碱(ACh)有浓度依赖性的抑制作用。非选择性阿片受体拮抗剂纳洛酮在完全逆转DAMGO对ACh释放的抑制作用的条件下不能拮抗伤害素的抑制作用。提示DAMGO和Neciceptin分别通过激活经典的(纳洛酮敏感的)阿片受体和新型的(纳洛酮不敏感的)阿片受体抑制胆碱能、副交感神经向呼吸道的传递。
The novel peptide, nociceptin and the μ‐opioid agonist [d‐Ala2, N‐Me‐Phe4, Gly5‐ol]‐enkephalin (DAMGO) produced a concentration‐dependent inhibition of electrical field stimulation (EFS)‐evoked release of acetylcholine (ACh) from cholinergic nerves innervating guinea‐pig trachea. The non‐selective opioid receptor antagonist, naloxone, did not antagonize the inhibitory action of nociceptin under conditions where the inhibition of ACh release evoked by DAMGO was completely reversed. It is suggested that DAMGO and nociceptin can inhibit cholinergic, parasympathetic neurotransmission to the airways via the activation of classical (naloxone‐sensitive) and novel (naloxone‐insensitive) opioid receptors, respectively.