Versatile Logic Devices Based on Programmable DNA-Regulated Silver-Nanocluster Signal Transducers
Versatile Logic Devices Based on Programmable DNA-Regulated Silver-Nanocluster Signal Transducers
复制标题
基于可编程 DNA 调节银纳米团簇信号传感器的多功能逻辑器件
DOI：
10.1002/chem.201103859
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发表时间：
2012-05-01
影响因子：
4.3
通讯作者：
Qu, Xiaogang
中科院分区：
文献类型：
--
作者：
Huang, Zhenzhen;Tao, Yu;Qu, Xiaogang
报道了一种可编程调控银纳米团簇荧光性质的DNA编码策略。通过利用DNA编码策略，水性AgNC被用作信号转换器，以将DNA输入转换成荧光输出，用于构建各种基于DNA的逻辑门（AND、OR、INHIBIT、XOR、NOR、XNOR、NAND和顺序逻辑门）。此外，一个生物分子键盘，能够构建填字游戏也被制造出来。这些基于AgNC的逻辑系统显示出几个优点，包括简单的换能器引入策略、通用设计和生物相容性操作。此外，这一概念证明为新一代信号转换器材料打开了大门，并为实际应用提供了通用生物分子逻辑器件的一般途径。
A DNA-encoding strategy is reported for the programmable regulation of the fluorescence properties of silver nanoclusters (AgNCs). By taking advantage of the DNA-encoding strategy, aqueous AgNCs were used as signal transducers to convert DNA inputs into fluorescence outputs for the construction of various DNA-based logic gates (AND, OR, INHIBIT, XOR, NOR, XNOR, NAND, and a sequential logic gate). Moreover, a biomolecular keypad that was capable of constructing crossword puzzles was also fabricated. These AgNC-based logic systems showed several advantages, including a simple transducer-introduction strategy, universal design, and biocompatible operation. In addition, this proof of concept opens the door to a new generation of signal transducer materials and provides a general route to versatile biomolecular logic devices for practical applications.