Slowing fastest finger movements of the dominant hand with low-frequency rTMS of the hand area of the primary motor cortex
Slowing fastest finger movements of the dominant hand with low-frequency rTMS of the hand area of the primary motor cortex
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DOI：
10.1007/s00221-003-1719-7
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发表时间：
2004-03-01
影响因子：
2
通讯作者：
Ziemann, U
中科院分区：
文献类型：
--
作者：
Jäncke, L;Steinmetz, H;Ziemann, U
神经成像研究表明，主要手部运动区和小脑在控制手指敲击中起着关键作用，但它们在这一任务中的不同贡献尚不清楚。因此，我们使用重复经颅磁刺激(RTMS)在其虚拟损伤模式(1 Hz，10min，90%运动阈值)下，研究健康右手受试者右侧小脑(CB)、左侧主手运动区(M1)和右侧臂丛(PL，对照部位)的一过性中断对各种手指敲击任务(起搏手指敲击任务：PFT；最大速度敲击：TAPMAX，以及方便速度敲击：TAPCON)的影响。在TAPMAX任务中，左侧M1的rTMS减慢了右手的手指敲击速度。这一效应消除了TAPMAX任务中的右手优势。此外，左侧M1的rTMS导致在TAPCON期间双手的攻丝速度较慢。RTMS对割胶速度或割胶变异性没有其他影响。研究结果表明，M1对于产生最快的手指运动是必不可少的。
Neuroimaging studies suggest that the primary hand motor area and the cerebellum play a pivotal role in the control of finger tapping, but their differential contribution in this task is unknown. We used therefore repetitive transcranial magnetic stimulation (rTMS) in its virtual lesion mode (1 Hz, 10 min, 90% of motor threshold) to study the effects of transient disruption of the right lateral cerebellum (CB), the left primary hand motor area (M1), and the right brachial plexus (PL, control site) on various finger tapping tasks (paced finger tapping task: PFT; tapping with maximum speed: TAPMAX, and tapping with convenient speed: TAPCON) in healthy right-handed subjects. RTMS of the left M1 slowed finger tapping speed of the right hand in the TAPMAX task. This effect eliminated the right hand superiority in the TAPMAX task. In addition, rTMS of the left M1 resulted in slower tapping speeds for both hands during TAPCON. There were no other effects of rTMS on tapping speed or tapping variability. Findings indicate that M1 is essential for generating fastest finger movements.