Long noncoding RNAs in gastric cancer carcinogenesis and metastasis
Long noncoding RNAs in gastric cancer carcinogenesis and metastasis
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DOI：
10.1093/bfgp/elw011
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发表时间：
2017-05-01
影响因子：
4
通讯作者：
Nikpour, Parvaneh
中科院分区：
文献类型：
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作者：
Nasrollahzadeh-Khakiani, Mojdeh;Emadi-Baygi, Modjtaba;Nikpour, Parvaneh
最近对人类转录组的研究，最突出的是DNA元件百科全书项目，揭示了意想不到的非编码rna （ncrna）数量。长链非编码rna （Long noncoding RNAs, lncRNAs）通常是指一组多聚腺苷化的长链ncRNAs，其长度为100 ~ 200 nt。lncRNAs是肿瘤生物学的重要组成部分，许多lncRNAs被发现在各种癌症类型中异常表达。它们参与了癌症发生、发展、转移和治疗反应的许多方面。胃癌（GC）是全球癌症死亡的第三大原因。尽管目前的预期寿命和存活率有所提高，但大多数患者在癌症进展到晚期时才被诊断出来。因此，揭示气相色谱的分子机制以发现早期生物标志物是迫切需要的。随着GC中表达不受调控的lncrna的列表稳步扩大，这些分子为开发GC特异性生物标志物提供了来源。在这篇综述中，我们将介绍和讨论那些在GC中表达不受调控的lncrna。
Recent studies of the human transcriptome, most prominently by the ENCyclopedia Of DNA Elements project, have revealed an unexpected number of noncoding RNAs (ncRNAs). Long noncoding RNAs (lncRNAs) are typically referred to a heterogeneous group of polyadenylated long ncRNAs, with a length of> 200 nt. LncRNAs constitute an integral part of tumor biology, with many lncRNAs discovered to be aberrantly expressed in various cancer types. They are involved in many aspects of cancer pathogenesis from its initiation to progression, metastasis and treatment response. Gastric cancer (GC) is the third leading cause of cancer death worldwide. Despite the current improvements of life expectancy and survival rate, most of the patients are diagnosed when their cancer has been progressed to advanced stages. Therefore, unraveling the molecular mechanisms of GC to find early-stage biomarkers is urgent. As the list of lncRNAs with deregulated expression in GC is steadily expanding, these molecules offer a source for developing GC-specific biomarkers. In this review, we will present and discuss those lncRNAs whose expression has been shown to be deregulated in GC.