Thermal enhancement of radiation damage in previously irradiated skin.
Thermal enhancement of radiation damage in previously irradiated skin.
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先前受辐射皮肤的辐射损伤的热增强。
DOI：
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发表时间：
1985
影响因子：
2.6
通讯作者：
S. Somaia
中科院分区：
文献类型：
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作者：
M. Law;R. Ahier;S. Somaia
在照射后不同时间观察了小鼠耳对单纯热疗、单纯X射线或X射线合并热疗的反应，直至一年。最初的X射线治疗，无论是单次剂量17GY或34GY，分10次在11天内给予，都会引起相同的皮肤反应(几只耳朵出现一小块湿润的脱屑)，并对后续治疗的反应产生相同的影响。在之前的照射后3-12个月，仅对热的反应就增加了，因此在43.5摄氏度下引起坏死所需的加热时间大约是年龄匹配的对照组的70%。仅对X光的反应也增加了。然而，先前的照射对急性放射性皮炎和晚期畸形的易感性有不同的影响。对于急性放射性皮炎，在以前接受过辐射的耳朵中获得给定反应所需的X射线剂量大约是年龄匹配的对照组所需剂量的90%。对于6个月时的畸形，剂量约为70%。预先照射对轻度热疗前6分钟(43.5℃，15分钟)X射线反应的影响与对单独X射线的反应相同。因此，热增强比(TER)，即引起效应所需的X射线剂量除以热所需的剂量，并不取决于先前的照射。急性放射性皮炎和晚期畸形的TER均为1.4。
The responses of the mouse ear to hyperthermia alone, X rays alone or X rays combined with heat were investigated at various times up to one year after prior irradiation. The initial X-ray treatments, either a single dose of 17 Gy or 34 Gy given as 10 fractions in 11 days, caused the same skin reactions (a small area of moist desquamation in a few ears) and had the same effects on the responses to subsequent treatments. The response to heat alone was increased at 3-12 months after prior irradiation, so that the heating time at 43.5 degrees C required to cause necrosis was about 70% of that in age-matched controls. The responses to X rays alone were also increased. Prior irradiation, however, had different effects on the susceptibilities to develop acute radiodermatitis and late deformity. For acute radiodermatitis, the X-ray dose required to obtain a given response in previously irradiated ears was about 90% of the dose required in age-matched controls. For deformity at 6 months, the dose was about 70%. Prior irradiation had the same effects on the responses to X rays given 6 min before mild hyperthermia (43.5 degrees C, 15 min) as on those to X rays alone. As a consequence, the thermal enhancement ratio (TER), i.e., the dose of X rays required alone to cause an effect divided by that required with heat, did not depend on previous irradiation. The TER was 1.4 for both acute radiodermatitis and late deformity.