The selective serotonin reuptake inhibitor paroxetine decreases breakpoint of rats engaging in a progressive ratio licking task for sucrose and quinine solutions.
The selective serotonin reuptake inhibitor paroxetine decreases breakpoint of rats engaging in a progressive ratio licking task for sucrose and quinine solutions.
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DOI：
10.1093/chemse/bjs096
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发表时间：
2013-03
期刊：
影响因子：
3.5
通讯作者：
C. Mathes;Jillian R. Gregson;A. Spector
中科院分区：
文献类型：
--
作者：
C. Mathes;Jillian R. Gregson;A. Spector
已显示增加的多巴胺能活性降低摄取的动机，这可能部分涉及味觉过程。在这里，我们研究了帕罗西汀，一种选择性5-羟色胺再摄取抑制剂，食欲反应的首选和避免的味道解决方案，使用渐进的比例（PR）的任务，其中舔作为操作。训练雄性Sprague-Dawley大鼠（n = 8/味觉刺激）对蔗糖或奎宁浓度系列的固定和PR强化时间表作出反应。蔗糖的性能进行了评估，而大鼠部分食物和水的限制和非剥夺，水和奎宁的性能进行了评估，而大鼠被剥夺了水。然后，给大鼠腹腔注射溶剂（10%二甲基亚砜，1 mL/kg，ip）或帕罗西汀（5 mg/kg，-1h），并在PR时间表上测量大鼠对蔗糖（非剥夺时）或对水和奎宁（剥夺时）的反应。帕罗西汀降低了断点，断点定义为操作性（例如，干）舔在最终的增强比例，对于水，奎宁，和蔗糖。这表明，在不同的剥夺状态下，一般全身性增加的多巴胺能活性降低了基于食欲的反应，首选和非首选的流体。
Increased serotonergic activity has been shown to reduce motivation to ingest, which may involve, in part, gustatory processes. Here, we examined the effect of paroxetine, a selective serotonin reuptake inhibitor, on appetitive responding for a preferred and an avoided taste solution using a progressive ratio (PR) task in which licking was employed as the operant. Male Sprague-Dawley rats (n = 8/taste stimulus) were trained to respond for a concentration series of sucrose or quinine on fixed and PR schedules of reinforcement. Performance for sucrose was assessed while the rats were partially food- and water-restricted and nondeprived, and performance for water and quinine was assessed while the rats were water-deprived. Then, the rats were injected with vehicle (10% dimethyl sulfoxide, 1mL/kg intraperitoneal [ip], -1h) or paroxetine (5mg/kg), and their responding on a PR schedule for sucrose measured when the rats were nondeprived or for water and quinine when the rats were water-deprived. Paroxetine decreased breakpoint, which was defined as the number of operant (e.g., dry) licks in the final reinforced ratio, for water, quinine, and sucrose. This demonstrates that a general systemic increase in serotonergic activity decreases the appetitive-based responses to both preferred and nonpreferred fluids under different deprivation states.