Trilateral retinoblastoma: a systematic review and meta-analysis
Trilateral retinoblastoma: a systematic review and meta-analysis
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DOI：
10.1016/s1470-2045(14)70336-5
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发表时间：
2014-09-01
期刊：
影响因子：
51.1
通讯作者：
Moll, Annette C.
中科院分区：
文献类型：
--
作者：
de Jong, Marcus C.;Kors, Wijnanda A.;Moll, Annette C.
背景：大约5%的RB1基因生殖系突变的视网膜母细胞瘤儿童有发展成三边视网膜母细胞瘤-眼内视网膜母细胞瘤合并组织学上相似的脑肿瘤的风险，最常见于松果体。我们的目的是提供三边视网膜母细胞瘤已发表数据的系统概述，并分析生存率如何变化。方法在Medline和Embase检索1966年1月1日至2014年4月14日期间发表的评估三边视网膜母细胞瘤病例的科学文献。我们采用Kaplan-Meier方法和Cox比例风险回归对生存率进行了荟萃分析，在原始研究的基础上进行分层，以解释研究间的异质性。我们纳入了90项研究，174例三边视网膜母细胞瘤患者。1995年以前诊断的松果体三边视网膜母细胞瘤患者的5年生存率从6% （95% CI 2-15）增加到44% (26-61
Background About 5% of children with retinoblastoma from germline mutation of the RB1 gene are at risk of developing trilateral retinoblastoma-intraocular retinoblastoma combined with a histologically similar brain tumour, most commonly in the pineal gland. We aimed to provide a systematic overview of published data for trilateral retinoblastoma, and to analyse how survival has changed.Methods We searched Medline and Embase for scientific literature published between Jan 1, 1966, and April 14, 2014, that assessed trilateral retinoblastoma cases. We undertook a meta-analysis of survival with the Kaplan-Meier method and Cox proportional hazards regression, stratified on the basis of the original study, to account for between-study heterogeneity.Findings We included 90 studies, with 174 patients with trilateral retinoblastoma. 5-year survival after pineal trilateral retinoblastoma increased from 6% (95% CI 2-15) in patients diagnosed before 1995, to 44% (26-61; p