HEART-RATE-VARIABILITY AND SUDDEN-DEATH SECONDARY TO CORONARY-ARTERY DISEASE DURING AMBULATORY ELECTROCARDIOGRAPHIC MONITORING
HEART-RATE-VARIABILITY AND SUDDEN-DEATH SECONDARY TO CORONARY-ARTERY DISEASE DURING AMBULATORY ELECTROCARDIOGRAPHIC MONITORING
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DOI：
10.1016/0002-9149(87)90990-8
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发表时间：
1987-07-01
影响因子：
2.8
通讯作者：
SINGER, DH
中科院分区：
文献类型：
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作者：
MARTIN, GJ;MAGID, NM;SINGER, DH
分析了5例在动态心电图监测中突然死亡的患者的资料。其中3例患者还根据2个最近开发的心率（HR）变异性指数进行了评估。其中之一，连续5分钟的RR间期在24小时内平均的标准差，已被报道为迷走神经张力的推定指数。与20例正常志愿者的HR变异性结果进行了比较。所有病例均因室性心动过速变性为室颤而猝死。早周期（3例）和晚周期（2例）室性早搏均引发终末心律失常。在室颤发作前1小时，观察到心室异位活动密度增加。由标准偏差测量的HR变异性在突然死亡的患者中显著（p < 0.01）较低（30 ± 0.01）。10 ms）比正常受试者（76 . ±. 14 ms）。这些研究结果支持的建议，心率变异性分析可能是有用的，在确定患者的猝死风险较高。
Data are analyzed from 5 patients who dies suddenly during ambulatory electrocardiographic monitoring. Three of the patients were also assessed in terms of 2 recently developed indexes of heart rate (HR) variability. One of these, the standard deviation of RR intervals during successive 5-minute segments averaged over 24 hours, has been reported to be a putative index of vagal tone. Comparisons were made with HR variability findings in 20 normal volunteers. Sudden death was due to ventricular tachycardia degenerating into ventricular fibrillation in all cases. Both early (3 patients) and late cycle (2 patients) ventricular premature conplexes initiated the terminal dysrhythmia. An increased density of ventricular ectopic activity was noted in the hour before onset of ventricular fibrillation. HR variability as measured by the standard deviation was significantly (p < 0.01) lower in the patient who died suddently (30 .+-. 10 ms) than in the normal subjects (76 .+-. 14 ms). These findings support suggestions that HR variability analysis may be useful in identifying patients at a higher risk of sudden death.