Entrained neuronal activity to periodic visual stimuli in the primate striatum compared with the cerebellum
Entrained neuronal activity to periodic visual stimuli in the primate striatum compared with the cerebellum
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DOI：
10.7554/elife.48702
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发表时间：
2019-09-06
期刊：
影响因子：
7.7
通讯作者：
Tanaka, Masaki
中科院分区：
文献类型：
--
作者：
Kameda, Masashi;Ohmae, Shogo;Tanaka, Masaki
节律性事件在基底节和小脑中招募神经元活动，但它们的作用仍然难以捉摸。在试图检测等时视觉刺激的单个遗漏的猴子中，我们发现尾状核中的神经元依次对每个刺激显示出更多的活动，而在小脑齿状核中的神经元显示出活动减少。大部分尾状核神经元和所有小脑神经元的放电调制与刺激间隔成正比，但四分之一的尾状核神经元表现出明显的时程调谐。此外，小脑群体活动的时间进程很好地预测了刺激时间，而尾状核的群体活动时间进程反映了反应潜伏期的随机变化。对相应记录部位的电刺激证实了在检测刺激遗漏中的因果作用。这些结果提示，纹状体神经元可能代表周期性反应的准备，而小脑核神经元可能在周期性事件的时间预测中发挥作用。
Rhythmic events recruit neuronal activity in the basal ganglia and cerebellum, but their roles remain elusive. In monkeys attempting to detect a single omission of isochronous visual stimulus, we found that neurons in the caudate nucleus showed increased activity for each stimulus in sequence, while those in the cerebellar dentate nucleus showed decreased activity. Firing modulation in the majority of caudate neurons and all cerebellar neurons was proportional to the stimulus interval, but a quarter of caudate neurons displayed a clear duration tuning. Furthermore, the time course of population activity in the cerebellum well predicted stimulus timing, whereas that in the caudate reflected stochastic variation of response latency. Electrical stimulation to the respective recording sites confirmed a causal role in the detection of stimulus omission. These results suggest that striatal neurons might represent periodic response preparation while cerebellar nuclear neurons may play a role in temporal prediction of periodic events.